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J-GLOBAL ID：200902276670899800   Reference number：04A0760108

Therapeutic effects of streptococcal preparation OK-432 on atopic dermatitis-like lesions in NC/Nga mice: possible shift from a Th2- to Th1-predominance

NC/Ngaマウスのアトピー性皮膚炎様病変に対する連鎖球菌製剤(OK-432)の治療効果:Th2優位からTh1優位への偏位の可能性

Author (4)： HORIUCHI Y (Nagaski Univ. School of Medicine, Nagasaki, JPN) ,  BAE S (Nagaski Univ. School of Medicine, Nagasaki, JPN) ,  KATAYAMA I (Nagaski Univ. School of Medicine, Nagasaki, JPN) ,  NISHIOKA K (Tokyo Medical and Dental Univ., Tokyo, JPN)
Material： Journal of Dermatological Science  (J Dermatol Sci)
Volume： 35  Issue： 3  Page： 187-197  Publication year： Sep. 2004 
JST Material Number： W1280A  ISSN： 0923-1811  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *atopic dermatitis ,...
Semi thesaurus term： *picibanil ,...

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JST classification (3)： Basic dermatology  (GF01020Y) ,  Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Reference (40)：

• ABBAS, AK. Functional diversity of helper T lymphocytes. Nature. 1996, 383, 787-793
• GREWE, M. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today. 1998, 19, 359-361
• RENZ, H. Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-γ. J Invest Dermatol. 1992, 99, 403-408
• OHKI, O. Functional CD86 (B7-2/B70) is predominantly expressed on Langerhans cells in atopic dermatitis. Br J Dermatol. 1997, 136, 838-845
• JIRAPONGSANANURUK, O. Leung DY... Enhanced expression of B7.2 (CD86) in patients with atopic dermatitis : a potential role in the modulation of IgE synthesis. J Immunol. 1998, 160, 4622-1627

Terms in the title (12)： NC ,  マウス ,  アトピー性皮膚炎 ,  病変 ,  連鎖球菌 ,  製剤 ,  OK-432 ,  治療効果 ,  Th2 ,  Th1 ,  偏位 ,  可能性