Art

J-GLOBAL ID：200902279017832820   Reference number：03A0132554

Synthesis of Non-Competitive Inhibitors of Sphingomyelinases with Significant Activity.

顕著な活性を有する非競争的スフィンゴミエリナーゼ阻害剤の合成

Author (8)： YOKOMATSU T (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  MURANO T (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  AKIYAMA T (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  KOIZUMI J (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  SHIBUYA S (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  TSUJI Y (Fukuoka Univ., Fukuoka, JPN) ,  SOEDA S (Fukuoka Univ., Fukuoka, JPN) ,  SHIMENO H (Fukuoka Univ., Fukuoka, JPN)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 13  Issue： 2  Page： 229-236  Publication year： Jan. 20, 2003 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *phosphonate ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=03A0132554&from=J-GLOBAL&jstjournalNo=W0248A") }}

JST classification (2)： Organop phosphorus compounds  (CF08040N) ,  Synthesis of drugs  (GV01030F)

Substance index (20)： Scyphostatin ,  N-Stearoyl-1-O-[[2-(trimethylaminio)ethyl]oxylatophosphinyl]sphingosine ,  2-[[(3S,4R,5E)-1,1-Difluoro-3-(stearoylamino)-4-hydroxy-5-nonadecenyl]oxylatophosphinyloxy]ethyltrimethylaminium ,  [(2R,3R,4R)-1,1-Difluoro-2,4-dihydroxy-3-(hexadecanoylamino)-4-phenylbutyl]phosphonic acid ,  (1S,2S)-2-Amino-1-phenyl-1,3-propanediol ,  N-[(1S,2S)-1-[tert-Butyldiphenylsiloxymethyl]-2-hydroxy-2-phenylethyl]carbamic acid tert-butyl ester ,  N-[(1S,2R)-1-[tert-Butyldiphenylsiloxymethyl]-2-hydroxy-2-phenylethyl]carbamic acid tert-butyl ester ,  (4S)-2,2-Dimethyl-4β-(hydroxymethyl)-5β-phenyloxazolidine-3-carboxylic acid tert-butyl ester ,  (4S)-2,2-Dimethyl-4β-[(1R)-1-hydroxy-2-(diethoxyphosphinyl)-2,2-difluoroethyl]-5β-phenyloxazolidine-3-carboxylic acid tert-butyl ester ,  (4S)-2,2-Dimethyl-4β-[2-(diethoxyphosphinyl)-2,2-difluoroethyl]-5β-phenyloxazolidine-3-carboxylic acid tert-butyl ester ,  [(2R,3R,4R)-1,1-Difluoro-2,4-dihydroxy-3-(hexadecanoylamino)-4-phenylbutyl]phosphonic acid diethyl ester ,  [(3S,4R)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid diethyl ester ,  [(3S,4R)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid ,  [[(4R)-2,2-Dimethyl-5α-(tert-butoxycarbonylamino)-6β-phenyl-1,3-dioxane-4β-yl]difluoromethyl]phosphonic acid diethyl ester ,  (4S)-2,2-Dimethyl-4β-(hydroxymethyl)-5α-phenyloxazolidine-3-carboxylic acid tert-butyl ester ,  (4S)-2,2-Dimethyl-4β-[(1R)-1-hydroxy-2-(diethoxyphosphinyl)-2,2-difluoroethyl]-5α-phenyloxazolidine-3-carboxylic acid tert-butyl ester ,  (4S)-2,2-Dimethyl-4β-[2-(diethoxyphosphinyl)-2,2-difluoroethyl]-5α-phenyloxazolidine-3-carboxylic acid tert-butyl ester ,  [(3S,4S)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid diethyl ester ,  [(3S,4S)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid ,  [(3S,4S)-1,1-Difluoro-3-amino-4-(hexadecanoyloxy)-4-phenylbutyl]phosphonic acid

Terms in the title (4)： 活性 ,  競争 ,  スフィンゴミエリナーゼ ,  阻害剤