Art

J-GLOBAL ID：200902279027831326   Reference number：09A0525965

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase

IκBキナーゼの1,6-ジヒドロイミダゾ[4,5-d]ピロロ[2,3-b]ピリジン-4-アミン由来の阻害剤の合成、初期SARおよび生物学的評価

Author (18)： KEMPSON James (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  GUO Junqing (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  DAS Jagabandhu (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  MOQUIN Robert V. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  SPERGEL Steven H. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  WATTERSON Scott H. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  LANGEVINE Charles M. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  DYCKMAN Alaric J. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  PATTOLI Mark (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  BURKE James R. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  YANG Xiaoxia (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  GILLOOLY Kathleen M. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  MCINTYRE Kim W. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  CHEN Laishun (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  DODD John H. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  MCKINNON Murray (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  BARRISH Joel C. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA) ,  PITTS William J. (Bristol-Myers Squibb Res. and Dev., Princeton, NJ 08543-4000, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 19  Issue： 10  Page： 2646-2649  Publication year： May. 15, 2009 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Terms in the title (6)： IκBキナーゼ ,  ピリジン-4-アミン ,  阻害剤 ,  初期 ,  SAR ,  生物学的評価