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J-GLOBAL ID：200902279271206026   Reference number：03A0501429

Synthesis and Conformational Analysis of (E)-9,10-Dehydroepothilone B: A Suggestive Link between the Chemistry and Biology of Epothilones.

(E)-9,10-デヒドロエポチロンBの合成及び配座解析 エポチロン類の化学と生物学の間の暗示的結合

Author (9)： YOSHIMURA F (Sloan-Kettering Inst. Cancer Res., NY, USA) ,  RIVKIN A (Sloan-Kettering Inst. Cancer Res., NY, USA) ,  GABARDA A E (Sloan-Kettering Inst. Cancer Res., NY, USA) ,  CHOU T-C (Columbia Univ., NY, USA) ,  DONG H (Columbia Univ., NY, USA) ,  SUKENICK G (Columbia Univ., NY, USA) ,  MOREL F F (Univ. Notre Dame, IN, USA) ,  TAYLOR R E (Univ. Notre Dame, IN, USA) ,  DANISHEFSKY S J (Sloan-Kettering Inst. Cancer Res., NY, USA)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 42  Issue： 22  Page： 2518-2521  Publication year： Jun. 06, 2003 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *macrolide antibiotics ,...

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JST classification (2)： Eight or more-membered heterocyclic compounds  (CF07120T) ,  Synthesis of antibiotics  (GX04000Z)

Substance index (6)： Epothilone B ,  Desoxyepothilone B ,  9,10-trans-Didehydroepothilone D ,  (E)-9,10-DehydroepothiloneB ,  (4S,7R,8S,9S,10E,13S,14R,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-13,14-epoxy-1-oxacyclohexadeca-10-ene-2,6-dione ,  (4S,7R,8S,9S,13S,14R,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-13,14-epoxy-1-oxacyclohexadecane-2,6-dione

Terms in the title (5)： 配座解析 ,  エポチロン類 ,  化学 ,  生物学 ,  暗示