Art

J-GLOBAL ID：200902279337764343   Reference number：03A0552702

Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Neuropathy and Gastroparesis

糖尿病性神経障害および胃不全麻ひに与えるアルドースレダクターゼ阻害剤,エパルレスタットの効果

Author (8)： OKAMOTO H (Kochi Red Cross Hospital, Kochi) ,  NOMURA M (Univ. Tokushima, Tokushima) ,  NAKAYA Y (Univ. Tokushima, Tokushima) ,  UEHARA K (Univ. Tokushima, Tokushima) ,  SAITO K (Univ. Tokushima, Tokushima) ,  KIMURA M (Kochi Red Cross Hospital, Kochi) ,  CHIKAMORI K (Kochi Red Cross Hospital, Kochi) ,  ITO S (Univ. Tokushima, Tokushima)
Material： Internal Medicine  (Intern Med)
Volume： 42  Issue： 8  Page： 655-664  Publication year： Aug. 2003 
JST Material Number： Z0157B  ISSN： 0918-2918  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： electrogastrography

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JST classification (3)： Clinical application of enzyme preparations and inhibitor preparations  (GW21020H) ,  Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Substance index (1)： Epalrestat

Reference (31)：

• 1) Rundles RW. Diabetic neuropathy. Medicine 24: 111-160, 1945.
• 2) Kassander P. Asymptomatic gastric retention in diabetics (gastroparesis diabeticoram). Ann Intern Med 48: 797-812, 1958.
• 3) Koch KL, Stern RM, Stewart WR, Vasey MW. Gastric emptying and gastric myoelectrical activity in patients with diabetic gastroparesis: effect of long-term domperidone treatment. Am J Gastroenterol 84: 1069-1075,1989.
• 4) Goto Y, Hotta N, Shigeta Y, et al. A placebo-controlled double-blind study of epalrestat (ONO-2235) in patients with diabetic neuropathy. Diabet Med 10 Suppl 2: 39S-43S, 1993.
• 5) Steele JW, Faulds D, Goa KL. Epalrestat. A review of its pharmacology, and therapeutic potential in late-onset complications of diabetes mellitus. Drugs Aging 3: 532-555, 1993.

Terms in the title (4)： 糖尿病性神経障害 ,  胃不全麻ひ ,  アルドースレダクターゼ阻害剤 ,  エパルレスタット