Art

J-GLOBAL ID：200902280291412534   Reference number：09A0690592

Efficacy of mizoribine pulse therapy in patients with rheumatoid arthritis who show a reduced or insufficient response to infliximab

インフリキシマブに対する反応が減弱したか不十分な関節リウマチ患者におけるミゾリビンパルス療法の効果

Author (10)： HORIKOSHI Masanobu (Univ. Tsukuba, Tsukuba, JPN) ,  ITO Satoshi (Univ. Tsukuba, Tsukuba, JPN) ,  ISHIKAWA Mizue (Univ. Tsukuba, Tsukuba, JPN) ,  UMEDA Naoto (Univ. Tsukuba, Tsukuba, JPN) ,  KONDO Yuya (Univ. Tsukuba, Tsukuba, JPN) ,  TSUBOI Hiroto (Univ. Tsukuba, Tsukuba, JPN) ,  HAYASHI Taichi (Univ. Tsukuba, Tsukuba, JPN) ,  GOTO Daisuke (Univ. Tsukuba, Tsukuba, JPN) ,  MATSUMOTO Isao (Univ. Tsukuba, Tsukuba, JPN) ,  SUMIDA Takayuki (Univ. Tsukuba, Tsukuba, JPN)
Material： Modern Rheumatology  (Mod Rheumatol)
Volume： 19  Issue： 3  Page： 229-234  Publication year： 2009 
JST Material Number： L5142A  ISSN： 1439-7595  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (2)： Clinical application of anti-inflammatory drugs  (GW15020E) ,  Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D)

Substance index (2)： Mizoribine ,  Methotrexate

Reference (19)：

• MAINI, R. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate : a randomized phase III trial. Lancet. 1999, 354, 1932-1939
• LIPSKY, PE. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Eng J Med. 2000, 343, 1594-1602
• ST CLAIR, EW. Combination of infliximab and methotrexate therapy for early rheumatoid arthritis. A randomized, controlled trial. Arthritis Rheum. 2004, 50, 3432-3443
• ISHIKAWA, H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999, 6, 575-597
• KOYAMA, H. Genetic and biochemical studies on the activation and cytotoxic mechanism of bredinin, a potent inhibitor of purine biosynthesis in mammalian cells. Biochem Pharmacol. 1983, 32, 3547-3553

Terms in the title (6)： インフリキシマブ ,  減弱 ,  関節リウマチ ,  患者 ,  ミゾリビン ,  パルス療法