Art

J-GLOBAL ID：200902283160604810   Reference number：09A0596103

Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720

アポトーシスの一因となっている関節リウマチの滑膜線維芽細胞におけるスフィンゴシン類縁体FTY720によるスフィンゴシンキナーゼ2の発現

Author (9)： KAMADA Kazuo (Ehime Univ. Graduate School of Medicine) ,  ARITA Norimasa (Ehime Univ. Graduate School of Medicine) ,  TSUBAKI Takahito (Ehime Prefectural Central Hospital) ,  TAKUBO Nobuo (Takubo Rheumatism and Orthopedics Clinic) ,  FUJINO Takahiro (Ehime Univ., Ehime, JPN) ,  SOGA Yoshiko (Ehime Univ. Graduate School of Medicine) ,  MIYAZAKI Tatsuhiko (Ehime Univ. Graduate School of Medicine) ,  YAMAMOTO Haruyasu (Ehime Univ., Ehime, JPN) ,  NOSE Masato (Ehime Univ. Graduate School of Medicine)
Material： Pathology International  (Pathol Int)
Volume： 59  Issue： 6  Page： 382-389  Publication year： Jun. 2009 
JST Material Number： W0853A  ISSN： 1320-5463  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (1)： Musculoskeletal diseases  (GG03000T)

Substance index (2)： Fingolimod Hydrochloride ,  Sphingosine-1-phosphate

Reference (53)：

• WORDSWORTH, P. Polygenic susceptibility in rheumatoid arthritis. Ann Rheum Dis. 1991, 50, 343-346
• MACGREGOR, AJ. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 2000, 43, 30-37
• NOSE, M. Genetic basis of the complex pathological manifestations of collagen disease : Lessons from MRL/Ipr and related mouse models. Int Rev Immunol. 2000, 19, 473-498
• KAMOGAWA, J. Arthritis in MRL/Ipr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum. 2002, 46, 1067-1074
• NEUMANN, E. Functional genomics of fibroblasts. Curr Opin Rheumatol. 2004, 16, 238-245

Terms in the title (8)： アポトーシス ,  関節リウマチ ,  滑膜線維芽細胞 ,  スフィンゴシン ,  類縁体 ,  FTY720 ,  スフィンゴシンキナーゼ2 ,  発現