Art

J-GLOBAL ID：200902283384610157   Reference number：09A0389165

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

がん治療の新たな手法としてのNEDD8活性化酵素阻害薬

Author (35)： SOUCY Teresa A. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  SMITH Peter G. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  MILHOLLEN Michael A. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  BERGER Allison J. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  GAVIN James M. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  ADHIKARI Sharmila (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  BROWNELL James E. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  BURKE Kristine E. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  CARDIN David P. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  CRITCHLEY Stephen (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  CULLIS Courtney A. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  DOUCETTE Amanda (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  GARNSEY James J. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  GAULIN Jeffrey L. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  GERSHMAN Rachel E. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  LUBLINSKY Anna R. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  MCDONALD Alice (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  MIZUTANI Hirotake (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  NARAYANAN Usha (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  OLHAVA Edward J. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  PELUSO Stephane (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  REZAEI Mansoureh (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  SINTCHAK Michael D. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  TALREJA Tina (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  THOMAS Michael P. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  TRAORE Tary (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  VYSKOCIL Stepan (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  WEATHERHEAD Gabriel S. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  YU Jie (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  ZHANG Julie (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  DICK Lawrence R. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  CLAIBORNE Christopher F. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  ROLFE Mark (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  BOLEN Joseph B. (Millennium Pharmaceuticals, Inc., Massachusetts, USA) ,  LANGSTON Steven P. (Millennium Pharmaceuticals, Inc., Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 458  Issue： 7239  Page： 732-736  Publication year： Apr. 09, 2009 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,  enzyme ,  proteasome ,  *antitumor drug ,  protein metabolism ,  Apoptosis ,  human ,  tumor cell ,  inhibition of multiplication ,  Cell Proliferation ,  Proteins ,  ubiquitin-activating enzyme ,  Mus musculus ,  Cullin Proteins ,  Ubiquitin-Protein Ligases ,  Myomorpha
Semi thesaurus term： NEDD8活性化酵素 ,  キュリン-RINGリガーゼ ,  ubiquitin ligase

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Pevonedistat

Terms in the title (4)： がん治療 ,  手法 ,  NEDD8 ,  阻害薬