Art

J-GLOBAL ID：200902284717457552   Reference number：06A0400603

The Mannich Reaction of Malonates with Simple Imines Catalyzed by Bifunctional Cinchona Alkaloids: Enantioselective Synthesis of β-Amino Acids

二機能性キナアルカロイド類を触媒としたマロン酸エステルと簡単なイミンとのMannich反応 β-アミノ酸のエナンチオ選択的合成

Author (3)： SONG Jun (Brandeis Univ., Massachusetts) ,  WANG Yi (Brandeis Univ., Massachusetts) ,  DENG Li (Brandeis Univ., Massachusetts)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 128  Issue： 18  Page： 6048-6049  Publication year： May. 10, 2006 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： asymmetric reaction ,...

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JST classification (3)： Aliphatic carboxylic esters,anhydrides,acid halides,acyl peroxides  (CF03210P) ,  Aromatic monocyclic aldehydes  (CF05160X) ,  Stereochemistry of organic reaction  (CF02130V)

Substance index (44)： 9-[3,5-Bis(trifluoromethyl)phenylthiourea]epiquinine ,  (9R)-6′-Methoxy-9-[3-[3,5-bis(trifluoromethyl)phenyl]thioureido]cinchonan ,  (S)-3-(tert-Butoxycarbonylamino)-3-(3-vinylphenyl)propionic acid ,  (3S)-N-(tert-Butoxycarbonyl)-3-phenyl-β-alanine ,  3-Oxo-4-methylpentanoic acid allyl ester ,  3-Oxopentanoic acid allyl ester ,  N-Boc-Cyclohexylmethyleneamine ,  2-Thenylidenecarbamic acid tert-butyl ester ,  N-(tert-Butoxycarbonyl)furan-2-methanimine ,  N-(tert-Butoxycarbonyl)propane-1-imine ,  N-(tert-Butoxycarbonyl)-1,3-benzodioxole-5-methaneimine ,  2-Methylbenzylidenecarbamic acid tert-butyl ester ,  3-Vinylbenzylidenecarbamic acid tert-butyl ester ,  3-Methylbenzylidenecarbamic acid tert-butyl ester ,  4-(Trifluoromethyl)benzylidenecarbamic acid tert-butyl ester ,  N-(4-Chlorobenzylidene)-tert-butoxycarbonylamine ,  N-Boc-4-Fluorobenzylideneamine ,  N-(4-Methylbenzylidene)-tert-butoxycarbonylamine ,  N-Boc-4-Methoxybenzylideneamine ,  N-(tert-Butoxycarbonyl)pentane-1-imine ,  rel-(R^*)-1-(tert-Butoxycarbonylamino)-1-phenyl-3-pentanone ,  rel-(R^*)-1-(tert-Butoxycarbonylamino)-1-phenyl-4-methyl-3-pentanone ,  rel-(R^*)-4-(tert-Butoxycarbonylamino)-4-phenyl-2-butanone ,  rel-2-[(R^*)-(tert-Butoxycarbonylamino)(1,3-benzodioxole-5-yl)methyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-(tert-Butoxycarbonylamino)(2-thienyl)methyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-(tert-Butoxycarbonylamino)(2-furanyl)methyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-(tert-Butoxycarbonylamino)cyclohexylmethyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-1-(tert-Butoxycarbonylamino)propyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-1-(tert-Butoxycarbonylamino)pentyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-2-methylbenzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-3-vinylbenzyl]malonic acid diallyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-3-methylbenzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-4-(trifluoromethyl)benzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-4-chlorobenzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-4-fluorobenzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-4-methylbenzyl]malonic acid dimethyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-4-methylbenzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)-4-methoxybenzyl]malonic acid dibenzyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)benzyl]malonic acid diallyl ester ,  rel-2-[(R^*)-α-(tert-Butoxycarbonylamino)benzyl]malonic acid dibenzyl ester ,  Allyl acetoacetate ,  Malonic acid diallyl ester ,  Malonic acid dimethyl ester ,  Malonic acid dibenzyl

Terms in the title (8)： 機能性 ,  キナアルカロイド ,  触媒 ,  マロン酸エステル ,  イミン ,  Mannich反応 ,  アミノ酸 ,  エナンチオ選択的合成