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J-GLOBAL ID：200902284884476569   Reference number：09A0582852

Discovery and antibacterial activity of glabramycin A-C from Neosartorya glabra by an antisense strategy

アンチセンス戦略によるNeosartorya glabraからのグラブラマイシンA-Cの発見と抗細菌活性

Author (12)： JAYASURIYA Hiranthi (Merck Res. Lab., NJ, USA) ,  ZINK Deborah (Merck Res. Lab., NJ, USA) ,  BASILIO Angela (Merck Sharp & Dohme de Espana, Madrid, ESP) ,  VICENTE Francisca (Merck Sharp & Dohme de Espana, Madrid, ESP) ,  COLLADO Javier (Merck Sharp & Dohme de Espana, Madrid, ESP) ,  BILLS Gerald (Merck Sharp & Dohme de Espana, Madrid, ESP) ,  GOLDMAN Mary Lee (Merck Res. Lab., NJ, USA) ,  MOTYL Mary (Merck Res. Lab., NJ, USA) ,  HUBER Joann (Merck Res. Lab., NJ, USA) ,  DEZENY Gabe (Merck Res. Lab., NJ, USA) ,  BYRNE Kevin (Merck Res. Lab., NJ, USA) ,  SINGH Sheo B (Merck Res. Lab., NJ, USA)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 62  Issue： 5  Page： 265-269  Publication year： May. 2009 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： minimal inhibitory concentration ,...
Semi thesaurus term： Neosartorya glabra ,...

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JST classification (1)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (3)： Glabramycin A ,  (2E,4E,6E)-7-[(1S,6S,11R,11aS)-1,6,7,8,9,10,11,11a-Octahydro-6-methyl-4,12-dioxo-1,11-propano-4H-2,5-dioxa-2H-cyclopentacyclodecene-3-yl]-2,4,6-heptatrienoic acid ,  Glabramycin C

Reference (28)：

• POEHLSGAARD, J. The bacterial ribosome as a target for antibiotics. Nat. Rev. Microbiol. 2005, 3, 870-881
• SINGH, S. B. Empirical antibacterial drug discovery-foundation in natural products. Biochem. Pharmacol. 2006, 71, 1006-1015
• RAMAKRISHNAN, V. Ribosome structure and the mechanism of translation. Cell. 2002, 108, 557-572
• CULVER, G. M. Assembly of the 30S ribosomal subunit. Biopolymers. 2003, 68, 234-249
• OGLE, J. M. Insights into the decoding mechanism from recent ribosome structures. Trends Biochem. Sci. 2003, 28, 259-266

Terms in the title (6)： 戦略 ,  Neosartorya ,  グラブ ,  ラマイシン ,  発見 ,  抗細菌活性