Art

J-GLOBAL ID：200902286076200931   Reference number：07A0515617

Vitamin K2 inhibits the proliferation of HepG2 cells by up-regulating the transcription of p21 gene

ビタミンK2はp21遺伝子の転写アップレギュレーションによるHepG2細胞増殖を抑制する

Author (13)： LIU Weidong (Hyogo Coll. of Medicine, Hyogo) ,  NAKAMURA Hideji (Hyogo Coll. of Medicine, Hyogo) ,  YAMAMOTO Teruhisa (Hyogo Coll. of Medicine, Hyogo) ,  IKEDA Naoto (Hyogo Coll. of Medicine, Hyogo) ,  SAITO Masaki (Hyogo Coll. of Medicine, Hyogo) ,  OHNO Masao (Hyogo Coll. of Medicine, Hyogo) ,  HARA Naoki (Hyogo Coll. of Medicine, Hyogo) ,  IMANISHI Hiroyasu (Hyogo Coll. of Medicine, Hyogo) ,  SHIMOMURA Soji (Hyogo Coll. of Medicine, Hyogo) ,  YAMAMOTO Tetsuo (Hyogo Coll. of Medicine, Hyogo) ,  SAKAI Toshiyuki (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  NISHIGUCHI Shuhei (Hyogo Coll. of Medicine, Hyogo) ,  HADA Toshikazu (Hyogo Coll. of Medicine, Hyogo)
Material： Hepatology Research  (Hepatol Res)
Volume： 37  Issue： 5  Page： 360-365  Publication year： May. 2007 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,...
Semi thesaurus term： p27

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Other vitamins  (EB07070D)

Substance index (1)： Vitamin K2(30)

Reference (20)：

• CHLEBOWSHI, RT. Vitamin K in the treatment of cancer. Cancer Treat Rev. 1985, 12, 49-63
• FURIE, B. Molecular basis of vitamin K-dependent gamma-carboxylation. Blood. 1990, 75, 1753-1762
• WANG, Z. The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology. 1995, 22, 876-882
• HITOMI, M. In vitro and in vivo antitumor effects of vitamin K5 on hepatocellular carcinoma. Int J Oncol. 2005, 26, 1337-1344
• OTSUKA, M. Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology. 2004, 40, 243-251

Terms in the title (6)： ビタミンK2 ,  p21遺伝子 ,  転写 ,  アップレギュレーション ,  HepG2細胞 ,  増殖