Art

J-GLOBAL ID：200902290237743962   Reference number：03A0575925

Retinoic acids exert direct effects on T cells to suppress T_h1 development and enhance T_h2 development via retinoic acid receptors.

レチノイン酸はレチノイン酸受容体経由でTh1発生を抑制しTh2発生を促進するためにT細胞に直接作用する

Author (3)： IWATA M (Mitsubishi Kagaku Inst. Life Sci., Tokyo, JPN) ,  ESHIMA Y (Mitsubishi Kagaku Inst. Life Sci., Tokyo, JPN) ,  KAGECHIKA H (Univ. Tokyo, Tokyo, JPN)
Material： International Immunology  (Int Immunol)
Volume： 15  Issue： 8  Page： 1017-1025  Publication year： Aug. 2003 
JST Material Number： W0116A  ISSN： 0953-8178  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： retinoic acid receptor ,...
Semi thesaurus term： immunological reaction ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=03A0575925&from=J-GLOBAL&jstjournalNo=W0116A") }}

JST classification (1)： Immunological reaction in general  (ED03010T)

Substance index (7)： Tretinoin ,  9-cis-Retinoic acid ,  Ionomycin ,  Phorbol 12-myristate 13-acetate ,  LE-540 ,  LE-135 ,  Tamibarotene

Reference (46)：

• CANTORNA, M. T. In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess T_h1 and insufficient T_h2 function. J. Immunol. 1994, 152, 1515
• RACKE, M. K. Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. J. Immunol. 1995, 154, 450
• CUI, D. High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice. J. Nutr. 2000, 130, 1132
• HOYOS, B. The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors. J. Exp. Med. 2000, 192, 835
• TICKLE, C. Vertebrate limb development. Annu. Rev. Cell. Biol. 1994, 10, 121

Terms in the title (6)： レチノイン酸 ,  レチノイン酸受容体 ,  Th1 ,  Th2 ,  促進 ,  T細胞