Art

J-GLOBAL ID：200902290678834491   Reference number：08A1107489

Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line

ニコチンはマウス前骨芽細胞株においてサイクリンD1のアップレギュレーションと関連して細胞増殖を誘導し,p53調節と関連して細胞分化を阻害する

Author (10)： SATO Tsuyoshi (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  ABE Takahiro (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  NAKAMOTO Norimichi (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  TOMARU Yasuhisa (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  KOSHIKIYA Noboru (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  NOJIMA Junya (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  KOKABU Shoichiro (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  SAKATA Yasuaki (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  KOBAYASHI Akio (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...) ,  YODA Tetsuya (Dep. of Oral and Maxillofacial Surgery, Fac. of Medicine, Saitama Medical Univ., 38 Moro-hongou, Moroyama-machi ...)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 377  Issue： 1  Page： 126-130  Publication year： Dec. 05, 2008 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *osteoblast ,  cultured cell ,  *cell proliferation ,  *cell differentiation ,  *bone metabolism ,  cell cycle ,  p53 protein ,  cyclin D1 ,  gene expression ,  up-regulation ,  down-regulation ,  alkaline phosphatase ,  microbial mineralization ,  nitrogen heterocyclic compound ,  tobacco alkaloid ,  alicyclic compound ,  bridged compound ,  secondary amine ,  drug
Semi thesaurus term： MC3T3-E1 cell ,  p53

JST classification (2)： Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Substance index (2)： Nicotine ,  Mecamylamine

Terms in the title (12)： ニコチン ,  マウス ,  前骨芽細胞 ,  株 ,  サイクリンD1 ,  アップレギュレーション ,  細胞増殖 ,  誘導 ,  p53 ,  調節 ,  細胞分化 ,  阻害