Art

J-GLOBAL ID：200902291250167551   Reference number：03A0768119

DEVELOPMENT OF NASAL DOSAGE FORM OF OXATOMIDE FOR RHINITIS

Oxatomide鼻腔内局所製剤の開発に関する基礎的検討

Author (5)： FURUBAYASHI TOMOYUKI (東光薬品工業 研究開発部) ,  KOBAYASHI YOICHI (東光薬品工業 研究開発部) ,  YAMASHITA SHINJI (摂南大 薬) ,  SAKANE TOSHIYASU (摂南大 薬) ,  KAWAUCHI HIDEYUKI (島根医大 耳鼻咽喉科)
Material： アレルギー  (Japanese Journal of Allergology)
Volume： 52  Issue： 10  Page： 992-998  Publication year： Oct. 30, 2003 
JST Material Number： Z0644A  ISSN： 0021-4884  CODEN： ARERAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *histamine H1-receptor blocker ,...
Semi thesaurus term： Caco-2 ,...

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JST classification (2)： Basic research of histaminergic drugs and antihistaminergic drugs  (GW06010V) ,  Pharmaceutical preparations in general  (GY02010Z)

Substance index (1)： Oxatomide

Reference (17)：

• 1) TASAKA K. Inhibitory effects of oxatomide on intracellular Ca mobilization, Ca uptake and histamine release, using rat peritoneal mast cells. Int Arch Allergy Appl Immunol. (1987) vol.83, p.348-353.
• 2) MANABE H. Oxatomide inhibits the release of chemical mediators from human lung tissues and from granulocytes. Int Arch Allergy Immunol. (1988) vol.87, p.91-97.
• 3) PAULUSSEN J. J. C. Infulence of the anti-allergic drug oxatomide on the signal transudation mechanism in a mast cell model. Eur. J. Pharmacol.. (1996) vol.312, p.121-130.
• 4) HIRAI S. Absorption of drugs from the nasal mucosa of rat. Int. J. Pharm.. (1981) vol.7, p.317.
• 5) HIDALGO I. J. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology. (1989) vol.96, p.736-749.

Terms in the title (4)： 鼻腔 ,  製剤 ,  開発 ,  基礎的検討