Art

J-GLOBAL ID：200902291425969877   Reference number：05A0310744

Synthesis of the New Furo[3,2-h]isoquinoline Alkaloid, TMC-120B from Aspergillus ustus

Aspergillus ustusからの新しいフロ[3,2-h]イソキノリンアルカロイド,TMC-120Bの合成

Author (7)： KUMEMURA Teppei (Fukuyama Univ., Hiroshima, JPN) ,  CHOSHI Tominari (Fukuyama Univ., Hiroshima, JPN) ,  HIRATA Aki (Fukuyama Univ., Hiroshima, JPN) ,  SERA Mitsuko (Fukuyama Univ., Hiroshima, JPN) ,  TAKAHASHI Yohhei (Fukuyama Univ., Hiroshima, JPN) ,  NOBUHIRO Junko (Fukuyama Univ., Hiroshima, JPN) ,  HIBINO Satoshi (Fukuyama Univ., Hiroshima, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 53  Issue： 4  Page： 393-397  Publication year： Apr. 01, 2005 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...
Semi thesaurus term： Aspergillus ustus ,...

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JST classification (1)： Quinolines,isoquinolines  (CF07096H)

Substance index (20)： TMC-120A ,  TMC-120B ,  TMC-120C ,  2,4-Bis(methoxymethoxy)benzaldehyde ,  2,4-Bis(methoxymethoxy)benzyl alcohol ,  tert-Butyldimethyl[2,4-bis(methoxymethoxy)benzyloxy]silane ,  2,6-Bis(methoxymethoxy)-3-(tert-butyldimethylsiloxymethyl)benzaldehyde ,  2,6-Bis(methoxymethoxy)-3-(tert-butyldimethylsiloxymethyl)benzaldehyde O-methyloxime ,  2,6-Bis(methoxymethoxy)-3-(hydroxymethyl)benzaldehyde O-methyloxime ,  2,4-Bis(methoxymethoxy)-3-[(methoxyimino)methyl]benzaldehyde ,  2,4-Bis(methoxymethoxy)-3-[(methoxyimino)methyl]benzoic acid ,  2-Hydroxy-4-(methoxymethoxy)-3-[(methoxyimino)methyl]benzaldehyde ,  [2-[(Methoxyimino)methyl]-3-(methoxymethoxy)-6-formylphenoxy]acetic acid methyl ester ,  [3-Hydroxy-6-formyl-2-(methoxyiminomethyl)phenoxy]acetic acid methyl ester ,  [2-[(Methoxyimino)methyl]-3-(trifluoromethylsulfonyloxy)-6-formylphenoxy]acetic acid methyl ester ,  [6-Formyl-2-(methoxyiminomethyl)-3-(1-propenyl)phenoxy]acetic acid methyl ester ,  (3-Methyl-7-formyl-8-isoquinolinyloxy)acetic acid methyl ester ,  3-Methyl-8-(2-oxo-2-methoxyethoxy)isoquinoline-7-carboxylic acid methyl ester ,  3-Hydroxy-7-methylfuro[3,2-h]isoquinoline-2-carboxylic acid methyl ester ,  7-Methyl-2,3-dihydrofuro[3,2-h]isoquinoline-2-one

Reference (25)：

• 1) Woodward R. B., Hoffmann R., “The Conservation of Orbital Symmetry,” Chap. 5, Verlag Chemie, Weinheim, 1970.
• 2) Marvel E. N., “Thermal Electrocyclic Reactions,” Chap. 2, Academic Press, New York, 1980.
• 3) Okamura W. H., de Lera A. R., “Comprehensive Organic Synthesis,” Vol. 5, eds. by Trost B. M., Fleming I., Paquette L. A., Pergamon Press, New York, 1991, pp. 699—750.
• 4) Hibino S., Sugino E., “Advances in Nitrogen Heterocycles,” Vol. 5, ed. by Moody C. J., JAI Press, Greenwich, 1995, pp. 699—750.
• 5) Choshi T., Yakugaku Zasshi, 121, 487—495 (2001).

Terms in the title (3)： Aspergillus ,  イソキノリンアルカロイド ,  TMC-120B