Art

J-GLOBAL ID：200902291579801588   Reference number：06A0142357

Carvedilol Inhibits Mitochondrial Oxygen Consumption and Superoxide Production During Calcium Overload in Isolated Heart Mitochondria

単離心臓ミトコンドリアのカルシウム過負荷中の酸素消費とスーパーオキシド産生のカルベジロールによる阻害

Author (9)： KAMETANI Ryosuke (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  MIURA Toshiro (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  HARADA Nozomu (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  SHIBUYA Masaki (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  WANG Ruijuan (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  TAN Hong (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  FUKAGAWA Yasuhiro (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  KAWAMURA Shuji (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine) ,  MATSUZAKI Masunori (The Dep. of Cardiovascular Medicine, Yamaguchi Univ. Graduate School of Medicine)
Material： Circulation Journal  (Circ J)
Volume： 70  Issue： 3  Page： 321-326 (J-STAGE)  Publication year： 2006 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mitochondria ,...
Semi thesaurus term： *oxygen consumption ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Clinical application of vasoactive drugs and hypotensive drugs  (GW07050U)

Substance index (2)： Carvedilol ,  Metoprolol

Reference (36)：

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• 2. Ruffolo RR Jr, Feuerstein GZ. Neurohormonal activation, oxygen free radicals, and apoptosis in the pathogenesis of congestive heart failure. J Cardiovasc Pharmacol 1998; 32: S22-S30.
• 3. Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, et al. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res 2000; 86: 152-157.
• 4. Ishikawa K, Kimura S, Kobayashi A, Sato T, Matsumoto H, Ujiie Y, et al. Increased reactive oxygen species and anti-oxidative response in mitochondrial cardiomyopathy. Circ J 2005; 69: 617-620.
• 5. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, et al. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation 2003; 107: 2459-2466.

Terms in the title (8)： 単離心臓 ,  ミトコンドリア ,  カルシウム ,  過負荷 ,  酸素消費 ,  スーパーオキシド ,  カルベジロール ,  阻害