Art

J-GLOBAL ID：200902291610403456   Reference number：09A0063264

Syntheses and Doxorubicin-Inclusion Abilities of β-Cyclodextrin Derivatives with a Hydroquinone α-Glycoside Residue Attached at the Primary Side

ヒドロキノンα-グリコシド残基が第一面側に結合したβ-シクロデキストリン誘導体の合成とドキソルビシン-包接能

Author (5)： ODA Yoshiki (The Noguchi Inst.) ,  MIURA Masumi (The Noguchi Inst.) ,  MIURA Masumi (Dep. of Nanochemistry, Fac. of Engineering, Tokyo Polytechnic Univ.) ,  HATTORI Kenjiro (Dep. of Nanochemistry, Fac. of Engineering, Tokyo Polytechnic Univ.) ,  YAMANOI Takashi (The Noguchi Inst.)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 57  Issue： 1  Page： 74-78 (J-STAGE)  Publication year： 2009 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cyclodextrin ,  *glycoside ,  phenol ether ,  chemical synthesis ,  *clathrate compound ,  antitumor drug ,  plasma resonance ,  surface plasmon ,  formation constant ,  amino sugar ,  quinone ,  glycoside (except carbohydrate) ,  polyphenol ,  deoxysugar ,  pyranoside ,  polynuclear aromatic compound ,  hydroxy ketone ,  polyol ,  Surface Plasmon Resonance
Semi thesaurus term： surface plasmon resonance

JST classification (2)： Polysaccharides  (CF10054P) ,  Molecular compounds  (CE02000C)

Substance index (6)： 1-O,4-[(4-Deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)]-6-[2-(4-O-β-D-galactopyranosyl-L-gluconoylamino)ethylthio]-4,6-dideoxy-α-D-glucopyranose ,  1-O,4-[(4-Deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)]-6-O-[3-[4-(α-D-glucopyranosyloxy)phenoxy]propyl]-4-deoxy-α-D-glucopyranose ,  1-O,4-[(4-Deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)]-6-[3-[4-(β-D-glucopyranosyloxy)phenoxy]propoxy]-4,6-dideoxy-α-D-glucopyranose ,  1-O,4-[(4-Deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)]-6-[4-(β-D-glucopyranosyloxy)phenoxyacetylamino]-4,6-dideoxy-α-D-glucopyranose ,  1-O,4-[(4-Deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)(4-deoxy-α-D-glucopyranose-4,1-O-diyl)]-6-[4-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyloxy]phenoxyacetylamino]-4,6-dideoxy-α-D-glucopyranose ,  Doxorubicin

Reference (25)：

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• 5) Our recent study also showed that several galactose–CyD conjugates having a phenyl group in the spacers between the galactose and β-CyD similarly had excellent inclusion associations of approximately 10^{5 m}−1 for the immobilized DXR. Oda Y., Yanagisawa H., Maruyama M., Hattori K., Yamanoi T., Bioorg. Med. Chem., 16, 8830—8840 (2008).

Terms in the title (4)： ヒドロキノン ,  グリコシド ,  シクロデキストリン誘導体 ,  ドキソルビシン