Art

J-GLOBAL ID：200902292815206242   Reference number：05A0938229

Role of Membrane-bound Syk in Collagen-stimulated Platelets and Abnormal Signal Transduction of Protein Tyrosine Kinases in Myelodysplastic Syndrome

コラーゲン刺激血小板における膜結合Sykの役割および骨髄異形成症候群における蛋白質チロシンキナーゼの異常なシグナル伝達

Author (4)： OBA-AZUMA Remi (Showa Univ. Fujigaoka Hospital, Yokohama, JPN) ,  TADA Jun-ichi (Showa Univ. Fujigaoka Hospital, Yokohama, JPN) ,  NIIKURA Haruo (Showa Univ. Fujigaoka Hospital, Yokohama, JPN) ,  OMINE Mitsuhiro (Showa Univ. Fujigaoka Hospital, Yokohama, JPN)
Material： Showa University Journal of Medical Sciences  (Showa Univ J Med Sci)
Volume： 17  Issue： 1  Page： 43-53  Publication year： Mar. 2005 
JST Material Number： L1154A  ISSN： 0915-6380  CODEN： SUMSEG  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： 蛋白質チロシンキナーゼ ,...

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JST classification (1)： Hematologic diseases  (GK03000F)

Reference (27)：

• 1) Clark EA, Shattil SJ and Brugge JS : Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci 19 : 464-469 (1994)
• 2) Dhar A and Shukla SD : Tyrosine kinases in platelet signalling. Br J Haematol 84: 1-7 (1993)
• 3) Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT and Brugge JS : Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125 FAK in platelets. J Cell Biol 119 : 905-912 (1992)
• 4) Nieswandt B and Watson SP : Platelet-collagen interaction : is GPVI the central receptor? Blood 102 : 449-461 (2003)
• 5) Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA and Shattil SJ : Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton. J Cell Biol 157 : 265-275 (2002)

Terms in the title (9)： コラーゲン ,  刺激 ,  血小板 ,  膜結合 ,  Syk ,  役割 ,  骨髄異形成症候群 ,  蛋白質チロシンキナーゼ ,  シグナル伝達