Art

J-GLOBAL ID：200902293450161623   Reference number：04A0287260

Role of Pharmacokinetic Effects in the Potentiation of Morphine Analgesia by L-Type Calcium Channel Blockers in Mice

マウスにおけるL-型カルシウムチャンネル遮断薬によるモルフィン鎮痛増強での薬物動力学的作用の役割

Author (7)： SHIMIZU N (Wakayama Medical Univ., Wakayama, JPN) ,  KISHIOKA S (Wakayama Medical Univ., Wakayama, JPN) ,  MAEDA T (Wakayama Medical Univ., Wakayama, JPN) ,  FUKAZAWA Y (Wakayama Medical Univ., Wakayama, JPN) ,  YAMAMOTO C (Wakayama Medical Univ., Wakayama, JPN) ,  OZAKI M (Niigata Univ. Pharmacy and Applied Life Sci., Niigata, JPN) ,  YAMAMOTO H (Wakayama Medical Univ., Wakayama, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 94  Issue： 3  Page： 240-245  Publication year： Mar. 01, 2004 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *narcotic analgesic ,...
Semi thesaurus term： *calcium channel blocker ,...

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JST classification (2)： Clinical application of addictive analgesics and narcotics  (GW03090K) ,  Clinical application of vasoactive drugs and hypotensive drugs  (GW07050U)

Substance index (4)： Morphine hydrochloride ,  Diltiazem ,  Verapamil ,  Nimodipine

Reference (36)：

• 1 Contreras E, Tamayo L, Amigo M. Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance. Eur J Pharmacol. 1988;148:463–466.
• 2 Antkiewicz-Michaluk L, Michaluk J, Romanska I, Vetulani J. Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine. Psychopharmacology (Berl). 1993;111:457–464.
• 3 Benedek G, Szikszay M. Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists. Pharmacol Res Commun. 1984;16:1009–1018.
• 4 Omote K, Sonoda H, Kawamata M, Iwasaki H, Namiki A. Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord. Anesthesiology. 1993;79:746–752.
• 5 Wei ZY, Karim F, Roerig SC. Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels. J Pharmacol Exp Ther. 1996;278:1392–1407.

Terms in the title (8)： マウス ,  型 ,  カルシウムチャンネル遮断薬 ,  モルフィン ,  鎮痛 ,  増強 ,  薬物動力学 ,  役割