Art

J-GLOBAL ID：200902294002452672   Reference number：06A0858225

Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer

癌の日本人患者でのSN-38グルクロン酸抱合に対するUGT1A1遺伝子のコード領域の多型の遺伝薬理学的影響

Author (10)： ARAKI Kazuhiro (Saitama Medical School, Saitama, JPN) ,  FUJITA Ken-ichi (Saitama Medical School, Saitama, JPN) ,  ANDO Yuichi (Saitama Medical School, Saitama, JPN) ,  NAGASHIMA Fumio (Saitama Medical School, Saitama, JPN) ,  YAMAMOTO Wataru (Saitama Medical School, Saitama, JPN) ,  ENDO Hisashi (Saitama Medical School, Saitama, JPN) ,  MIYA Toshimichi (Saitama Medical School, Saitama, JPN) ,  KODAMA Keiji (Saitama Medical School, Saitama, JPN) ,  NARABAYASHI Masaru (Saitama Medical School, Saitama, JPN) ,  SASAKI Yasutsuna (Saitama Medical School, Saitama, JPN)
Material： Cancer Science  (Cancer Sci)
Volume： 97  Issue： 11  Page： 1255-1259  Publication year： Nov. 2006 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *UGT1A1遺伝子 ,...

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JST classification (2)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Substance index (2)： SN-38 ,  SN-38 glucuronide

Reference (22)：

• MEYERHARDT, JA. Systemic therapy for colorectal cancer. N Engl J Med. 2005, 352, 476-487
• NODA, K. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 2002, 346, 85-91
• TADOKORO, J. Post-marketing surveillance (PMS) of all patients treated with irinotecan in Japan : clinical experience and ADR profile of 13 935 patients. Proc Am Soc Clin Oncol. 2002, 21, 259
• KUBOTA, K. The Four-Arm Cooperative Study (FACS) for advanced non-small-cell lung cancer (NSCLC). J Clin Oncol. 2004, 22, 618
• MATHIJSSEN, RH. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin Cancer Res. 2001, 7, 2182-2194

Terms in the title (8)： 癌 ,  日本人 ,  患者 ,  SN-38 ,  グルクロン酸抱合 ,  UGT1A1遺伝子 ,  多型 ,  遺伝薬理学