Art

J-GLOBAL ID：200902294024725770   Reference number：04A0649392

A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols

ポリエンマクロライドへの統一された方法 カンジジン及びナイスタチンポリオールの合成

Author (4)： KADOTA I (Univ. California, CA) ,  HU Y (Univ. California, CA) ,  PACKARD G K (Univ. California, CA) ,  RYCHNOVSKY S D (Univ. California, CA)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 101  Issue： 33  Page： 11992-11995  Publication year： Aug. 17, 2004 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *macrolide antibiotics ,...
Semi thesaurus term： amphotericin ,...

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JST classification (4)： Eight or more-membered heterocyclic compounds  (CF07120T) ,  Alkenes  (CF03030T) ,  Aliphatic alcohols  (CF03090H) ,  Synthesis of antibiotics  (GX04000Z)

Substance index (19)： Amphotericin B ,  Nystatin ,  Candidin (Streptomyces) ,  Rimocidin ,  (4R)-3-[(2R)-2-[(1R)-1-Hydroxy-2-(triisopropylsilyloxy)ethyl]-3-butenoyl]-4-benzyloxazolidine-2-one ,  (4R,5S,6S)-2,2-Dimethyl-4-(iodomethyl)-5-vinyl-6-allyl-1,3-dioxane ,  (3R,4R)-4,6-Bis(benzyloxy)hexane-1,3-diol ,  (6R)-2,2-Dimethyl-6-[(1R)-1,3-bis(benzyloxy)propyl]-1,3-dioxane-4-carbonitrile ,  (3S,5S)-3-(Trimethylsilyloxy)-5-(tert-butyldimethylsilyloxy)-7-(benzyloxy)heptanal ,  (6R)-2,2-Dimethyl-6-[(2S)-2-(tert-butyldimethylsilyloxy)-4-(benzyloxy)butyl]-1,3-dioxane-4-carbonitrile ,  (4R,6R)-2,2-Dimethyl-4-[[(4S,5S,6S)-2,2-dimethyl-5-vinyl-6-allyl-1,3-dioxane-4-yl]methyl]-6-[(1R)-1,3-bis(benzyloxy)propyl]-1,3-dioxane-4-carbonitrile ,  (2S,4R,6S,8S,9S,10S)-2-Methyl-4-[(1R)-1-(tert-butyldimethylsilyloxy)-3-bromopropyl]-8-allyl-9-vinyl-10-(tert-butyldimethylsilyloxy)-1,3,7-trioxaspiro[5.5]undecane ,  (3S,5S,7R,10R,11R,13S,15S,16S,17S)-1-(Benzyloxy)-3,10,15-tris(tert-butyldimethylsilyloxy)-5,7-(isopropylidenedioxy)-7-cyano-11,13-(ethylidenedioxy)-13,17-epoxy-16-vinyl-19-icosene ,  (3S,5S,7R,10R,11R,13S,15S,16S,17S)-1-Acetoxy-3,10,15-tris(tert-butyldimethylsilyloxy)-5,7-(isopropylidenedioxy)-7-cyano-11,13-(ethylidenedioxy)-13,17-epoxy-16-vinyl-19-icosene ,  (S)-3-Hydroxybutyric acid ethyl ,  (2E,4E,6E,8E,10E,12E,14S,15R,16S,17S)-14,16-Dimethyl-15-(tert-butyldimethylsilyloxy)-17-hydroxyoctadeca-2,4,6,8,10,12-hexaenal ,  (3R,5S,7R,10R,11R,13S,15S,16S,17S)-3,10,15-Tris(tert-butyldimethylsilyloxy)-5,7-(isopropylidenedioxy)-7-cyano-11,13-[[(1S)-ethylidene]dioxy]-13,17-epoxy-16-(methoxycarbonyl)-19-oxo-20-(diethoxyphosphinyl)icosanoic acid ,  (3R,5S,7R,10R,11R,13S,15S,16S,17S)-3,10,15-Tris(tert-butyldimethylsilyloxy)-5,7-(isopropylidenedioxy)-7-cyano-11,13-[[(1S)-ethylidene]dioxy]-13,17-epoxy-16-(methoxycarbonyl)-19-oxo-20-(diethoxyphosphinyl)icosanoic acid (1S,2S,3R,4S,5E,7E,9E,11E,13E,15E)-1,2,4-trimethyl-3-(tert-butyldimethylsilyloxy)-17-oxo-5,7,9,11,13,15-heptadecahexenyl ester ,  (3R,5S,7R,10R,11R,13S,15S,16S,17S,19R,20E,22E,24E,26E,28E,30E,32E,34S,35R,36S,37S)-3,10,15,35-Tetrakis(tert-butyldimethylsilyloxy)-5,7-(isopropylidenedioxy)-7-cyano-11,13-(ethylidenedioxy)-13,17-epoxy-16-(methoxycarbonyl)-19,37-dihydroxy-34,36-dimethyloctatriaconta-20,22,24,26,28,30,32-heptaenoic acid 1,37-lactone

Terms in the title (1)： カンジジン