Art

J-GLOBAL ID：200902294065808418   Reference number：08A0254216

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

ピルビン酸キナーゼのM2型スプライス・アイソフォームはがんの代謝と腫瘍増殖に重要である

Author (14)： CHRISTOFK Heather R. (Harvard Medical School, Massachusetts, USA) ,  VANDER HEIDEN Matthew G. (Harvard Medical School, Massachusetts, USA) ,  VANDER HEIDEN Matthew G. (Dana Farber Cancer Inst., Massachusetts, USA) ,  HARRIS Marian H. (Children’s Hospital, Massachusetts, USA) ,  RAMANATHAN Arvind (Broad Inst. of Harvard and MIT, Massachusetts, USA) ,  GERSZTEN Robert E. (Broad Inst. of Harvard and MIT, Massachusetts, USA) ,  GERSZTEN Robert E. (Massachusetts General Hospital, Massachusetts, USA) ,  GERSZTEN Robert E. (Harvard Medical School, Massachusetts, USA) ,  WEI Ru (Broad Inst. of Harvard and MIT, Massachusetts, USA) ,  FLEMING Mark D. (Children’s Hospital, Massachusetts, USA) ,  SCHREIBER Stuart L. (Broad Inst. of Harvard and MIT, Massachusetts, USA) ,  SCHREIBER Stuart L. (Harvard Univ., Massachusetts, USA) ,  CANTLEY Lewis C. (Harvard Medical School, Massachusetts, USA) ,  CANTLEY Lewis C. (Beth Israel Deaconess Medical Center, Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 452  Issue： 7184  Page： 230-233  Publication year： Mar. 13, 2008 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Pyruvate Kinase ,  tumor cell ,  effect ,  nude mouse ,  glycolytic pathway ,  Cell Proliferation ,  Alternative Splicing ,  molecular genetic phenomenon
Semi thesaurus term： alternative splicing ,  *M2型ピルビン酸キナーゼ ,  ワールブルク効果

JST classification (2)： Gene expression  (EC02040Q) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (4)： ピルビン酸キナーゼ ,  がん ,  代謝 ,  腫瘍増殖