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J-GLOBAL ID：200902294084694849   Reference number：09A0442226

Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

抗RAGE療法のためのヒト化したラット抗体のアフィニティー成熟:総合的変異誘発で示した相補性決定領域内部及び外部の高レベル変異柔軟性

Author (18)： FINLAY William J. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  CUNNINGHAM Orla (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  LAMBERT Matthew A. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  DARMANIN-SHEEHAN Alfredo (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  LIU Xuemei (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  FENNELL Brian J. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  MAHON Ciara M. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  CUMMINS Emma (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  WADE Jason M. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  O'SULLIVAN Cliona M. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland) ,  TAN Xiang Yang (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  PICHE Nicole (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  PITTMAN Debra D. (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  PAULSEN Janet (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  TCHISTIAKOVA Lioudmila (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  KODANGATTIL Sreekumar (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  GILL Davinder (Wyeth Res., 87 Cambridge Park Drive, Massachusetts, MA 02140, USA) ,  HUFTON Simon E. (Wyeth Res. Ireland, Conway Inst., Univ. Coll. Dublin, Belfield, Dublin 4, Ireland)
Material： Journal of Molecular Biology  (J Mol Biol)
Volume： 388  Issue： 3  Page： 541-558  Publication year： May. 08, 2009 
JST Material Number： D0124B  ISSN： 0022-2836  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *signal transduction receptor ,  *antibody ,  Rattus ,  affinity ,  mutagenesis ,  binding site ,  antigen receptor ,  immunoglobulin fragment ,  neutralizing antibody ,  Septicemia ,  experimental disease ,  monoclonal antibody ,  ribosome ,  genetic technique ,  mutant ,  immunoglobulin G ,  gene expression ,  Mus musculus ,  Amino Acid Sequence ,  bacterial infection (disease) ,  *humanized antibody ,  Complementarity Determining Regions ,  phage display method ,  *advanced glycosylation end product receptor ,  Myomorpha ,  molecular genetic phenomenon
Semi thesaurus term： *RAGE

JST classification (1)： Production and application of antigens,antibodies,complements  (ED04030W)

Terms in the title (11)： RAGE ,  療法 ,  ヒト ,  ラット ,  抗体 ,  アフィニティー ,  成熟 ,  変異誘発 ,  相補性決定領域 ,  高レベル ,  変異