Art

J-GLOBAL ID：200902294225765621   Reference number：09A0519366

Improvement of Dissolution Property of Poorly Water-soluble Drug by Using Dry Coating Method with Starches as Core-particles

デンプンを用いた乾式コーティング法による難水溶性薬物の溶解性改善

Author (4)： SONODA RYOICHI (科研製薬) ,  HORIBE MASASHI (科研製薬) ,  IWASAKI TOMOHIRO (大阪府大 大学院工学研究科) ,  WATANO SATORU (大阪府大 大学院工学研究科)
Material： 粉体工学会誌  (Journal of the Society of Powder Technology, Japan)
Volume： 46  Issue： 5  Page： 338-346  Publication year： May. 10, 2009 
JST Material Number： S0129A  ISSN： 0386-6157  CODEN： FKKADA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Starch ,...
Semi thesaurus term： non-steroidal anti-inflammatory agent ,...

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JST classification (3)： Pharmaceutical preparations in general  (GY02010Z) ,  Basic research of other drugs  (GW23010K) ,  Powder technology  (XD03010M)

Substance index (1)： Flurbiprofen

Reference (12)：

• 1) Yamamoto, K., M. Nakano, A. Takaichi and Y. Nakai : “Dissolution Rate and Bioavailability of Griseofulvin from a Ground Mixture with Microcrystalline Cellulose”, J. Pharm. Biopharm., 2, 487-493 (1974)
• 2) Takahata, H., Y. Nishioka and T. Osawa : “Teibunshiryou no suiyouseibussitsu tono kongoufunsai niyoru nannsuiyouseiyakubutsu no bisaika”, Powder Science and Engineering, 24, 53-59 (1992)
• 3) Kondo, N., T. Iwao, H. Masuda, K. Yamanouchi, Y. Ishihara, N. Yamada, T. Haga, Y. Ogawa and K. Yokoyama : “Improved Oral Absorption of a Poorly Water-soluble Drug, HO-221, by Wet-bead Milling Producing Particles in Submicron Region”, Chem. Pharm. Bull., 41, 737-740 (1993)
• 4) Samejima, M. : “Process for Micronizing Slightly-soluble Drug”, US patent, No. 5, 202, 129 (1993)
• 5) Sugimoto, M., T. Okagaki, S. Narisawa, Y. Koida and K. Nakajima : “Improvement of Dissolution Characteristics and Bioavailability of Poorly Water-soluble Drugs by Novel Cogrinding Method using Water-soluble Polymer”, Int. J. Pharm., 160, 11-19 (1998)

Terms in the title (4)： デンプン ,  コーティング ,  難水溶性薬物 ,  溶解性