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J-GLOBAL ID：200902294392352835   Reference number：06A0597390

THE IDEAL SYNTHETIC METHOD AIMED AT THE LEADS FOR AN α₂-BLOCKER, AN INHIBITOR OF BLOOD PLATELET AGGREGATION, AND AN ANTI-OSTEOPOROSIS AGENT

α₂-遮断薬,血小板凝集阻害薬,および抗骨粗しょう症薬のリード化合物を目指す理想的合成法

Author (8)： SOMEI Masanori (Kanazawa Univ., Ishikawa, JPN) ,  IWAKI Takako (Kanazawa Univ., Ishikawa, JPN) ,  YAMADA Fumio (Kanazawa Univ., Ishikawa, JPN) ,  TANAKA Yoshio (Toho Univ., Chiba, JPN) ,  SHIGENOBU Koki (Toho Univ., Chiba, JPN) ,  KOIKE Katsuo (Toho Univ., Chiba, JPN) ,  SUZUKI Nobuo (Kanazawa Univ., Ishikawa, JPN) ,  HATTORI Atsuhiko (Tokyo Medical and Dental Univ., Chiba, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 68  Issue： 8  Page： 1565-1569  Publication year： Aug. 01, 2006 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： alkoxylation ,...

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JST classification (2)： Condensed derivatives of pyrroles  (CF07077C) ,  Synthesis of drugs  (GV01030F)

Substance index (7)： Tryptamine ,  Melatonin ,  N-[2-(1-Acetyl-2,4,6-tribromo-5-methoxy-1H-indole-3-yl)ethyl]acetamide ,  1-Allyl-2,4,6-tribromomelatonin ,  SSH-BMI ,  2,4,6-Tribromo-1-propargylmelatonin ,  N-[2-(1-Tosyl-2,4,6-tribromo-5-methoxy-1H-indole-3-yl)ethyl]acetamide

Reference (9)：

• a) This report is Part 128 of a series entitled “The Chemistry of Indoles”. b) This is presented at the 126th Annual Meeting of Pharmaceutical Society of Japan: M. Somei, F. Yamada, T. Iwaki, A. Hattori, N. Suzuki, K. Shigenobu, and Y. Tanaka, Abstract Papers (4), Sendai, March 2006, p. 184. c) Part 127: K. Yamada, T. Izumi, F. Yamada, and M. Somei, Heterocycles, 2005, 66, 583.
• a) Definition of OR: M. Somei, Y. Fukui, M. Hasegawa, N. Oshikiri, and T. Hayashi, Heterocycles, 2000, 53, 1725; M. Somei, Yakugaku Zasshi, 1988, 108, 361; M. Somei, J. Synth. Org. Chem., 1982, 40, 387. b) Definitions of IPF and APF: M. Somei, F. Yamada, Y. Suzuki, S. Ohmoto, and H. Hayashi, Heterocycles, 2004, 64, 483.
• M. Somei, Abstract Papers, 111th Meeting of Hokuriku Branch, Pharmaceutical Society of Japan, Kanazawa, Dec., 2004, p. 1.
• M. Somei, K. Shigenobu, and Y. Tanaka, JP Patent 2004-280104, applied Sept.2004.
• M. Somei, K. Yamada, M. Hasegawa, M. Tabata, Y. Nagahama, H. Morikawa, and F. Yamada, Heterocycles, 1996, 43, 1855; M. Somei, JP Patent 1996-157475 [Chem. Abstr., 1996, 125, 195426y]; M. Somei, JP Patent 1991-31257 [Chem. Abstr., 1991, 114, 247138a].

Terms in the title (5)： 遮断薬 ,  血小板凝集阻害薬 ,  骨粗しょう症 ,  リード化合物 ,  合成法