Art

J-GLOBAL ID：200902295027652281   Reference number：09A0726529

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

ヘッジホッグシグナリングの阻害は膵臓癌のマウスモデルで化学療法のデリバリーを増強する

Author (40)： OLIVE Kenneth P. (Cancer Res. UK, Cambridge, GBR) ,  JACOBETZ Michael A. (Cancer Res. UK, Cambridge, GBR) ,  DAVIDSON Christian J. (Univ. Pennsylvania, PA, USA) ,  GOPINATHAN Aarthi (Cancer Res. UK, Cambridge, GBR) ,  GOPINATHAN Aarthi (Univ. Pennsylvania, PA, USA) ,  MCINTYRE Dominick (Cancer Res. UK, Cambridge, GBR) ,  HONESS Davina (Cancer Res. UK, Cambridge, GBR) ,  MADHU Basetti (Cancer Res. UK, Cambridge, GBR) ,  GOLDGRABEN Mae A. (Cancer Res. UK, Cambridge, GBR) ,  CALDWELL Meredith E. (Cancer Res. UK, Cambridge, GBR) ,  ALLARD David (Cancer Res. UK, Cambridge, GBR) ,  FRESE Kristopher K. (Cancer Res. UK, Cambridge, GBR) ,  DENICOLA Gina (Cancer Res. UK, Cambridge, GBR) ,  DENICOLA Gina (Univ. Pennsylvania, PA, USA) ,  FEIG Christine (Cancer Res. UK, Cambridge, GBR) ,  COMBS Chelsea (Univ. Pennsylvania, PA, USA) ,  WINTER Stephen P. (Cancer Res. UK, Cambridge, GBR) ,  IRELAND-ZECCHINI Heather (Cancer Res. UK, Cambridge, GBR) ,  REICHELT Stefanie (Cancer Res. UK, Cambridge, GBR) ,  HOWAT William J. (Cancer Res. UK, Cambridge, GBR) ,  CHANG Alex (Johns Hopkins Univ., MD, USA) ,  DHARA Mousumi (Johns Hopkins Univ., MD, USA) ,  WANG Lifu (Univ. Pennsylvania, PA, USA) ,  WANG Lifu (Shanghai Jiaotong Univ. School of Medicine, Shanghai, CHN) ,  RUECKERT Felix (Univ. Hospital Dresden, Dresden, DEU) ,  GRUETZMANN Robert (Univ. Hospital Dresden, Dresden, DEU) ,  PILARSKY Christian (Univ. Hospital Dresden, Dresden, DEU) ,  IZERADJENE Kamel (Univ. Washington, WA, USA) ,  HINGORANI Sunil R. (Univ. Washington, WA, USA) ,  HUANG Pearl (Merck and Co., PA, USA) ,  DAVIES Susan E. (Cambridge Univ., Cambridge, GBR) ,  PLUNKETT William (Univ. Texas, TX, USA) ,  EGORIN Merrill (Univ. Pittsburgh Medical Center, PA, USA) ,  HRUBAN Ralph H. (Johns Hopkins Univ., MD, USA) ,  WHITEBREAD Nigel (Infinity Pharmaceuticals, MA, USA) ,  MCGOVERN Karen (Infinity Pharmaceuticals, MA, USA) ,  ADAMS Julian (Infinity Pharmaceuticals, MA, USA) ,  IACOBUZIO-DONAHUE Christine (Johns Hopkins Univ., MD, USA) ,  GRIFFITHS John (Cancer Res. UK, Cambridge, GBR) ,  TUVESON David A. (Cancer Res. UK, Cambridge, GBR)
Material： Science
Volume： 324  Issue： 5933  Page： 1457-1461  Publication year： Jun. 12, 2009 
JST Material Number： E0078A  ISSN： 0036-8075  CODEN： SCIEA  Document type： Article
Article type： 解説  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *pancreatic tumor ,  mouse(animal) ,  experimental disease ,  *drug therapy ,  adenocarcinoma ,  sensitivity ,  human(primates) ,  gene manipulation ,  interstitial tissue ,  drug delivery system ,  halogeno sugar ,  riboside

JST classification (1)： Experimental treatment for tumors  (GE02040Y)

Substance index (1)： Gemcitabine

Terms in the title (6)： 阻害 ,  膵臓癌 ,  マウスモデル ,  化学療法 ,  デリバリー ,  増強