Art

J-GLOBAL ID：200902295496929855   Reference number：06A0969701

Inhibition of G Protein-Activated Inwardly Rectifying K⁺ Channels by the Antidepressant Paroxetine

抗欝薬のパロキセチンによるG蛋白質活性化内向き整流K⁺チャンネルの阻害

Author (3)： KOBAYASHI Toru (Dep. of Molecular Neuropathology, Brain Res. Inst., Niigata Univ., JPN) ,  WASHIYAMA Kazuo (Dep. of Molecular Neuropathology, Brain Res. Inst., Niigata Univ., JPN) ,  IKEDA Kazutaka (Div. of Psychobiology, Tokyo Inst. of Psychiatry, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 102  Issue： 3  Page： 278-287 (J-STAGE)  Publication year： 2006 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *potassium channel ,...
Semi thesaurus term： A1 adenosine receptor ,...

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JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Transport of cell membrane  (EF04020R)

Substance index (4)： Ethanol ,  Trazodon ,  Paroxetine ,  Milnacipran

Reference (58)：

• 1 Baldessarini RJ. Drugs and the treatment of psychiatric disorders: depression and anxiety disorders. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman & Gilman’s the pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill; 2001. p. 447–483.
• 2 Bourin M, Chue P, Guillon Y. Paroxetine: A review. CNS Drug Rev. 2001;7:25–47.
• 3 Stanton T, Bolden-Watson C, Cusack B, Richelson E. Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistamines. Biochem Pharmacol. 1993;45:2352–2354.
• 4 Fryer JD, Lukas RJ. Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function. J Neurochem. 1999;72:1117–1124.
• 5 Maertens C, Droogmans G, Verbesselt R, Nilius B. Block of volume-regulated anion channels by selective serotonin reuptake inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2002;366:158–165.

Terms in the title (6)： 抗欝薬 ,  パロキセチン ,  G蛋白質 ,  活性化 ,  内向き整流K+チャンネル ,  阻害