Art

J-GLOBAL ID：200902295633282090   Reference number：09A1242154

Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study

転移性結腸直腸癌でのFOLFOX,XELOX,FOLFIRI及びフルオロピリミジンを用いた第一線ベバシズマブの安全と有効性:BEAT研究

Author (12)： VAN CUTSEM E. (Univ. Hospital Gasthuisberg, Leuven, BEL) ,  RIVERA F. (Hospital Marques de Valdecilla, Santander, ESP) ,  BERRY S. (Univ. Toronto, Toronto, CAN) ,  KRETZSCHMAR A. (HELIOS-Klinikum Berlin, Berlin, DEU) ,  MICHAEL M. (Peter MacCallum Cancer Inst., Melbourne, AUS) ,  DIBARTOLOMEO M. (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ITA) ,  MAZIER M.-A. (Parexel, Paris, FRA) ,  CANON J.-L. (Centre Hospitalier Notre Dame Reine Fabiola, Charleroi, BEL) ,  GEORGOULIAS V. (Univ. General Hospital, Heraklion, GRC) ,  PEETERS M. (Univ. Hospital, Gent, BEL) ,  BRIDGEWATER J. (Univ. Coll. London Hospital, London) ,  CUNNINGHAM D. (Royal Marsden Hospital, Sutton, GBR)
Material： Annals of Oncology  (Ann Oncol)
Volume： 20  Issue： 11  Page： 1842-1847  Publication year： Nov. 2009 
JST Material Number： W0107A  ISSN： 0923-7534  CODEN： ANONE2  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *Metastatic colorectal cancer ,...

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JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (5)： Fluorouracil ,  Levofolinate calcium ,  CPT-11 ,  Leucovorin ,  Capecitabine

Reference (17)：

• Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 2001; 280: C1358-C1366.
• Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676.
• Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7: 987-989.
• Kabbinavar FF, Hambleton J, Mass RD et al. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005; 23: 3706-3712.
• Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350: 2335-2342.

Terms in the title (8)： 転移性結腸直腸癌 ,  FOLFOX ,  XELOX ,  FOLFIRI ,  フルオロピリミジン ,  ベバシズマブ ,  有効性 ,  研究