Art

J-GLOBAL ID：200902296173873547   Reference number：07A0188682

Saikokeishito Extract Exerts a Therapeutic Effect on α-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue

柴胡桂枝湯エキスはラットα-ナフチルイソチオシアネート誘導肝傷害に対し肝組織の好中球浸潤増加と酸化ストレスの低下により治療効果を示す

Author (6)： OHTA Yoshiji (Fujita Health Univ., Aichi, JPN) ,  KONGO-NISHIMURA Mutsumi (Fujita Health Univ., Aichi, JPN) ,  HAYASHI Takahiro (Fujita Health Univ. Hospital, Aichi, JPN) ,  KITAGAWA Akira (Chukyo Women’s Univ., Aichi, JPN) ,  MATSURA Tatsuya (Tottori Univ., Tottori, JPN) ,  YAMADA Kazuo (Tottori Univ., Tottori, JPN)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 40  Issue： 1  Page： 31-41  Publication year： Jan. 2007 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： immunological reaction

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JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (2)： 1-Naphthyl isothiocyanate ,  Glutathione

Reference (41)：

• [1] Plaa, G.L. and Priestly, B.G.: Intrahepatic cholestasis induced by drugs and chemicals. Pharmacol. Rev., 28, 207-273, 1977.
• [2] Roth, R.A. and Dahm, L.J.: Neutrophil- and glutathione-mediated hepatotoxicity of α-naphthylisothiocyanate. Drug Met. Rev., 29, 153-165, 1997.
• [3] Dahm, L.J., Schultze, A.E., and Roth, R.A.: An antibody of neutrophils attenuates α-naphthylisothiocyanate-induced liver injury. J. Pharmacol. Exp. Ther., 256, 412-420, 1991.
• [4] Hill, D.A. and Roth, R.A.: α-Naphthylisothiocyanate causes neutrophils to release factors that are cytotoxic to hepatocytes. Toxicol. Appl. Pharmacol., 148, 169-175, 1998.
• [5] Hill, D.A,, Jean, P.A., and Roth, R.A.: Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produces a factor that causes neutrophil-dependent hepatocellular injury in vitro. Toxicol. Sci., 47, 118-125, 1999.

Terms in the title (9)： 柴胡桂枝湯 ,  エキス ,  ラット ,  誘導 ,  肝傷害 ,  肝組織 ,  好中球浸潤 ,  酸化ストレス ,  治療効果