Art

J-GLOBAL ID：200902296358367109   Reference number：08A1243236

Antibacterial Novel Phenolic Diterpenes from Podocarpus macrophyllus D. DON

Podocarpus macrophyllus D. DONからの抗細菌作用を有する新規なフェノール性ジテルペン類

Author (10)： SATO Kimihiko (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci.) ,  SUGAWARA Keito (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci.) ,  TAKEUCHI Hirono (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci.) ,  PARK Hyun-sun (The Kochi Prefectural Makino Botanical Garden) ,  AKIYAMA Toshiyuki (The Kochi Prefectural Makino Botanical Garden) ,  KOYAMA Tetsuo (The Kochi Prefectural Makino Botanical Garden) ,  AOYAGI Yutaka (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci.) ,  TAKEYA Koichi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci.) ,  TSUGANE Takanori (Dep. of Basic Res., Lotte Central Lab. Co., Ltd.) ,  SHIMURA Susumu (Dep. of Basic Res., Lotte Central Lab. Co., Ltd.)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 56  Issue： 12  Page： 1691-1697 (J-STAGE)  Publication year： 2008 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tricyclic diterpene ,  *Podocarpus ,  bark ,  secondary metabolite ,  molecular structure ,  Electrospray Ionization Mass Spectrometry ,  proton magnetic resonance ,  13C NMR ,  two-dimensional NMR ,  antibacterial action ,  pathogen ,  crystal structure ,  metabolic pathway ,  aliphatic alcohol
Semi thesaurus term： Podocarpus macrophyllus

JST classification (2)： Diterpenes,sesterterpenes  (CF10023R) ,  Plant biochemistry  (EH01050J)

Substance index (9)： Methanol ,  12-Isopropyl-13-hydroxy-14-deisopropyltotarane-8,11,13-triene-19-oic acid ,  12-Isopropyl-13,19-dihydroxy-14-deisopropyltotarane-8,11,13-triene-7-one ,  2-Oxo-13-hydroxytotarane-8,11,13-triene-19-oic acid ,  7β,13-Dihydroxytotarane-8,11,13-triene-19-oic acid ,  7α-Methoxy-13-hydroxytotarane-8,11,13-triene-19-oic acid ,  13-Hydroxytotarane-6,8,11,13-tetraene-19-oic acid ,  7-Oxo-13-hydroxytotarane-8,11,13-triene-19-oic acid ,  3β,13,19-Trihydroxytotarane-8,11,13-triene

Reference (13)：

• 1) Saeki I., Sumitomo M., Kondo T., Holzforschung, 24, 83—86 (1970).
• 2) Hayashi T., Kakisawa H., Ito S., Chen Y. P., Hsu H.-Y., Tetrahedron Lett., 1972, 3385—3388 (1972).
• 3) Kodama M., Kabuto C., Sunagawa M., Ito S., Tetrahedron Lett., 1977, 2909—2910 (1977).
• 4) Omoto T., Yoshida O., Chem. Pharm. Bull., 28, 1894—1899 (1980).
• 5) Park H.-S., Takahashi Y., Fukaya H., Aoyagi Y., Takeya K., J. Nat. Prod., 66, 282—284 (2003).

Terms in the title (5)： Podocarpus ,  DON ,  抗細菌作用 ,  フェノール ,  ジテルペン