Art

J-GLOBAL ID：200902296440736392   Reference number：09A0331572

Studies toward the total synthesis of YW3699, a sesterterpenoid GPI biosynthesis inhibitor: preparation of the tri-substituted cyclooctene ring using the RCM reaction

セスタテルペノイドGPI生合成阻害剤YW3699の全合成に向けての研究: RCM反応を使った三置換シクロオクテン環の調製

Author (5)： MIZUTANI Reiko (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ., Yamashiro-cho, Tokushima 770-8514, JPN) ,  NAKASHIMA Katsuyuki (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ., Yamashiro-cho, Tokushima 770-8514, JPN) ,  SAITO Yoshinori (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ., Yamashiro-cho, Tokushima 770-8514, JPN) ,  SONO Masakazu (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ., Yamashiro-cho, Tokushima 770-8514, JPN) ,  TORI Motoo (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ., Yamashiro-cho, Tokushima 770-8514, JPN)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 50  Issue： 19  Page： 2225-2227  Publication year： May. 13, 2009 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： asymmetric synthesis ,  *ring-closing metathesis ,  *alicyclic ketone ,  *cyclic ether ,  olefin compound ,  Eumycetes ,  metabolite ,  drug ,  synthetic intermediate ,  stereoisomer
Semi thesaurus term： YW3699 ,  inhibitor

JST classification (2)： Three-membered heterocyclic compounds  (CF07050R) ,  Other condensed tricyclic carbocyclic compounds  (CF06080R)

Substance index (4)： YW-3699 ,  (7R)-7β-[[(5β)-2α-Allyl-6-oxabicyclo[3.1.0]hexane-1β-yl]carbonyl]-8α-isopropenyl-1,4-dioxaspiro[4.5]decane ,  (7R)-7β-[[(5α)-2α-Allyl-6-oxabicyclo[3.1.0]hexane-1α-yl]carbonyl]-8α-isopropenyl-1,4-dioxaspiro[4.5]decane ,  (1S)-6-Methyl-11-oxo-1β,11aβ-epoxy-2,3,3aα,4,6aβ,7,8,9,10,10aα,11,11a-dodecahydro-1H-benzo[a]cyclopenta[d]cyclooctene-9-one ethylene acetal

Terms in the title (9)： 生合成 ,  阻害剤 ,  全合成 ,  研究 ,  RCM ,  置換 ,  シクロオクテン ,  環 ,  調製