Art

J-GLOBAL ID：200902296818002597   Reference number：09A0508570

Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A

イソキノリンの効率的かつ立体選択的導入: コルチスタチンAの形式的全合成

Author (5)： YAMASHITA Shuji (Dep. of Chemistry, Graduate School of Sci., Tohoku Univ., Sendai 980-8578, JPN) ,  KITAJIMA Kazuki (Dep. of Chemistry, Graduate School of Sci., Tohoku Univ., Sendai 980-8578, JPN) ,  ISO Kentaro (Dep. of Chemistry, Graduate School of Sci., Tohoku Univ., Sendai 980-8578, JPN) ,  HIRAMA Masahiro (Dep. of Chemistry, Graduate School of Sci., Tohoku Univ., Sendai 980-8578, JPN) ,  HIRAMA Masahiro (Res. and Analytical Center for Giant Molecules, Graduate School of Sci., Tohoku Univ., Sendai 980-8578, JPN)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 50  Issue： 26  Page： 3277-3279  Publication year： Jul. 01, 2009 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： total synthesis ,  *steroid ,  *nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  stereospecific reaction ,  nucleophilic addition reaction ,  radical reaction ,  reduction (reaction) ,  carbamate ,  organosulphur compound ,  Isoquinolines ,  Thiocarbamates
Semi thesaurus term： thiocarbamate

JST classification (1)： Steroids  (CF10040O)

Substance index (13)： Cortistatin A ,  7-Iodoisoquinoline ,  1-Chloro-7-iodoisoquinoline ,  1-Chloro-7-bromoisoquinoline ,  3α-(tert-Butyldimethylsiloxy)-17-(7-isoquinolinyl)-5α-androstane-17-ol ,  3α-(tert-Butyldimethylsiloxy)-17-(1-chloro-7-isoquinolinyl)-5α-androstane-17-ol ,  3α-(tert-Butyldimethylsilyloxy)-17-(phenylthiocarbamoyloxy)-17-(1-chloro-7-isoquinolyl)-5α-androstane ,  17β-(tert-Butyldimethylsiloxy)-5,8α-epoxy-9,10-seco-9,19-cyclo-5α-androsta-10(19),9(11)-diene-1-one ,  (3S)-3α-Hydroxy-3aα-methyl-10aα,11aα-ethano-1,2,3,3a,4,7,8,9,10,10a,11a,11bβ-dodecahydro-11-oxa-11H-cyclopenta[a]anthracene-7-one ethylene acetal ,  17-Oxo-5,8α-epoxy-9,10-seco-9,19-cyclo-5α-androsta-10(19),9(11)-diene-1-one ethylene acetal ,  (3S)-3α-Hydroxy-3-(1-chloro-7-isoquinolinyl)-3aα-methyl-10aα,11aα-ethano-1,2,3,3a,4,7,8,9,10,10a,11a,11bβ-dodecahydro-11-oxa-11H-cyclopenta[a]anthracene-7-one ethylene acetal ,  (3S)-3α-(Phenylthiocarbamoyloxy)-3-(1-chloro-7-isoquinolinyl)-3aα-methyl-10aα,11aα-ethano-1,2,3,3a,4,7,8,9,10,10a,11a,11bβ-dodecahydro-11-oxa-11H-cyclopenta[a]anthracene-7-one ethylene acetal ,  17β-(7-Isoquinolyl)-5,8α-epoxy-9,10-seco-9,19-cyclo-5α-androsta-10(19),9(11)-diene-1-one

Terms in the title (4)： イソキノリン ,  立体 ,  コルチスタチンA ,  全合成