Art

J-GLOBAL ID：200902297395423007   Reference number：03A0385914

Facile Synthesis of Tilmicosin and Tylosin Related Haptens for Use as Protein Conjugates

蛋白質複合体として利用するためのチルミコシンとタイロシン関連ハプテンの簡便な合成

Author (3)： CREEMER L C (ELANCO Animal Health R&D, IN) ,  BEIER R C (Agricultural Res. Service, U.S. Dep. Agricultuate. TX) ,  KIEHL D E (ELANCO Animal Health R&D, IN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 56  Issue： 5  Page： 481-487  Publication year： May. 25, 2003 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： macrolide antibiotics ,...

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JST classification (3)： Production and application of antigens,antibodies,complements  (ED04030W) ,  Synthesis of antibiotics  (GX04000Z) ,  Other natural substances of biological origin  (CF10090R)

Substance index (10)： Tilmicosin ,  Tylosin ,  O-Mycaminosyltylonolide ,  (4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-Ethyl-4-hydroxy-6-[3-(dimethylamino)-3,6-dideoxy-β-D-glucopyranosyloxy]-7-[2-(3β,5β-dimethylpiperidino)ethyl]-15-(hydroxymethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione ,  (4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-Ethyl-4-hydroxy-6-[3-(dimethylamino)-3,6-dideoxy-β-D-glucopyranosyloxy]-7-[2-(3β,5β-dimethylpiperidino)ethyl]-15-(iodomethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione ,  (4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-Ethyl-4-hydroxy-6-[3-(dimethylamino)-3,6-dideoxy-β-D-glucopyranosyloxy]-7-[2-(3β,5β-dimethylpiperidino)ethyl]-15-[(3-aminopropylamino)methyl]-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione ,  (4R,5S,6S,7R,9R,11E,13E,15R,16R)-2,10-Dioxo-16-ethyl-4-hydroxy-6-[3-(dimethylamino)-4-O-(3-C-methyl-2,6-dideoxy-α-L-altropyranosyl)-3,6-dideoxy-β-D-glucopyranosyloxy]-15-(hydroxymethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-7-acetaldehyde ,  (4R,5S,6S,7R,9R,11E,13E,15S,16R)-2,10-Dioxo-16-ethyl-4-hydroxy-6-[3-(dimethylamino)-4-O-(3-C-methyl-2,6-dideoxy-α-L-altropyranosyl)-3,6-dideoxy-β-D-glucopyranosyloxy]-15-(iodomethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-7-acetaldehyde ,  (4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-Ethyl-4-hydroxy-6-[3-(dimethylamino)-4-O-(3-C-methyl-2,6-dideoxy-α-L-altropyranosyl)-3,6-dideoxy-β-D-glucopyranosyloxy]-7-(2-hydroxyethyl)-15-(iodomethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione ,  (4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-Ethyl-4-hydroxy-6-[3-(dimethylamino)-4-O-(3-C-methyl-2,6-dideoxy-α-L-altropyranosyl)-3,6-dideoxy-β-D-glucopyranosyloxy]-7-(2-hydroxyethyl)-15-[(3-aminopropylamino)methyl]-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione

Reference (11)：

• 1) DEBONO, M. & H. A. KIRST: C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics. U.S. Patent 4,820,695, April 11, 1989
• 2) DEBONO, M.; K. E. WILLARD, H. A. KIRST, J. A. WIND, G. D. GROUSE, E. V. TAO, J. T. VICENZI, E T. COUNTER, J. L. OTT, E. E. OSE & S. OMURA: Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. J. Antibiotics 42: 1253-1267, 1989
• 3) SCORNEAUX, B. & T. R. SHRYOCK: Intracellular accumulation, subcellular distribution, and efflux of tilmicosin in bovine mammary, blood, and lung cells. J. Dairy Sci. 82(6): 1202-1212, 1999
• 4) JACKMAN, R.; Y. I. SPENCER, J. J. SILVERLIGHT, S. A. MARSH & P. J. BELLERBY: Development of antibodies to tilmicosin and their use in the immunolocalization of the antibiotic in porcine lung tissue. J. Vet. Pharmacol. Therap. 20(Suppl. 1): 131-132, 1997
• 5) SILVERLIGHT, J. J.; A. J. BROWN & R. JACKMAN: Antisera to tilmicosin for use in ELISA and for immunohistochemistry. Food Agric. Immunol. 11(4): 321-328, 1999

Terms in the title (4)： 蛋白質複合体 ,  チルミコシン ,  タイロシン ,  ハプテン