Art

J-GLOBAL ID：200902297552141738   Reference number：08A0630180

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation

高LET放射はカスパーゼ9活性化を通して変異p53癌細胞におけるアポトーシスを増加させる

Author (8)： YAMAKAWA Nobuhiro (Nara Medical Univ., Nara) ,  TAKAHASHI Akihisa (Nara Medical Univ., Nara) ,  MORI Eiichiro (Nara Medical Univ., Nara) ,  IMAI Yuichiro (Nara Medical Univ., Nara) ,  FURUSAWA Yoshiya (National Inst. of Radiological Sci., Chiba, JPN) ,  OHNISHI Ken (Nara Medical Univ., Nara) ,  KIRITA Tadaaki (Nara Medical Univ., Nara) ,  OHNISHI Takeo (Nara Medical Univ., Nara)
Material： Cancer Science  (Cancer Sci)
Volume： 99  Issue： 7  Page： 1455-1460  Publication year： Jul. 2008 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *linear energy transfer ,...
Semi thesaurus term： Caspase 9 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=08A0630180&from=J-GLOBAL&jstjournalNo=W1423A") }}

JST classification (4)： Experimental treatment for tumors  (GE02040Y) ,  Tumors(=neoplasms)of tooth and mouth(=oral cavity)  (GT04000N) ,  Basic radiology  (GC04012H) ,  Biological function  (EB03040U)

Substance index (1)： Hoechst-33342

Reference (35)：

• PALME, CE. Current treatment options in squamous cell carcinoma of the oral cavity. Surg Oncol Clin North Am. 2004, 13, 47-70
• COOPER, JS. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004, 350, 1937-1944
• HOLLSTEIN, M. p53 mutations in human cancers. Science. 1991, 253, 49-53
• EFEYAN, A. p53 : guardian of the genome and policeman of the oncogenes. Cell Cycle. 2007, 6, 1006-1010
• VOUSDEN, KH. Live or let die : the cell's response to p53. Nat Rev Cancer. 2002, 2, 594-604

Terms in the title (8)： LET ,  放射 ,  カスパーゼ9 ,  活性化 ,  変異 ,  p53 ,  癌細胞 ,  アポトーシス