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J-GLOBAL ID：200902297764565791   Reference number：08A1151200

STRUCTURE-ACTIVITY RELATIONSHIP OF OKADAIC ACID, A POTENT PROTEIN PHOSPHATASES PP1 AND PP2A INHIBITOR: 24-epi-OKADAIC ACID AND A 18-MEMBERED LACTONE ANALOG

強力な蛋白質ホスファターゼPP1及びPP2Aの阻害剤,オカダ酸の構造活性相関 24-epi-オカダ酸及び18員環ラクトン類似体

Author (15)： KITA Masaki (Nagoya Univ., Nagoya, JPN) ,  KURAMOTO Makoto (Ehime Univ., Matsuyama, JPN) ,  CHIBA Tatsuhiko (Shizuoka Univ., Shizuoka, JPN) ,  YAMADA Akihiro (Nagoya Univ., Nagoya, JPN) ,  YAMADA Akihiro (Shizuoka Univ., Shizuoka, JPN) ,  YAMADA Nobuko (Shizuoka Univ., Shizuoka, JPN) ,  ISHIDA Takako (Shizuoka Univ., Shizuoka, JPN) ,  ISHIDA Takako (Sagami Chemical Res. Center, Sagamihara, JPN) ,  HAINO Takeharu (Sagami Chemical Res. Center, Sagamihara, JPN) ,  YAMADA Kaoru (Keio Univ., Yokohama, JPN) ,  YAMADA Kaoru (Nagoya Univ., Nagoya, JPN) ,  IJUIN Yasuharu (Sagami Chemical Res. Center, Sagamihara, JPN) ,  OHNO Osamu (Nagoya Univ., Nagoya, JPN) ,  UEMURA Daisuke (Keio Univ., Yokohama, JPN) ,  UEMURA Daisuke (Nagoya Univ., Nagoya, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 76  Issue： 2  Page： 1033-1042  Publication year： Nov. 01, 2008 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： structure-activity relationship ,...
Semi thesaurus term： cavity ,...

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JST classification (3)： Eight or more-membered heterocyclic compounds  (CF07120T) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (8)： Okadaic acid ,  24-epi-Okadaic acid ,  (1R,3R,6R,7E,9R,10S,12Z,14R,15R,18S,20R,23R,25S,27R)-9,12,20-Trimethyl-15,20-dihydroxy-24-methylene-25-[(1S,3S,4S,5R,8S)-1-hydroxy-3,5-dimethyl-4,8:8,12-diepoxydodecane-1-yl]-3,27-ethano-3,6:10,14:14,18-triepoxy-2,22,26-trioxabicyclo[21.4.0]heptacosane-7,12-diene-21-one ,  Methyl okadate ,  (25S)-24-Oxo-25-[(phenylthio)methyl]-24-deoxy-25-desmethylene-9,45-seco-10-demercapto-9,10-didehydroacanthifolicin methyl ester ,  (24S)-9,45-Seco-10-demercapto-9,10-didehydroacanthifolicin methyl ester ,  2-O-(Methylthiomethyl)-7-O,27-O-bis(tert-butyldimethylsilyl)-9,45-seco-10-demercapto-9,10-didehydroacanthifolicin methyl ester ,  (1R,3R,6R,7E,9R,10S,12Z,14R,15R,18S,20R,23R,25S,27R)-9,12,20-Trimethyl-15-(tert-butyldimethylsiloxy)-20-(methylthiomethoxy)-24-methylene-25-[(1S,3S,4S,5R,8S)-1-(tert-butyldimethylsiloxy)-3,5-dimethyl-4,8:8,12-diepoxydodecane-1-yl]-3,27-ethano-3,6:10,14:14,18-triepoxy-2,22,26-trioxabicyclo[21.4.0]heptacosane-7,12-diene-21-one

Reference (24)：

• A. Takai, C. Bialojan, M. Troschka, and J. C. Ruegg, FEBS Lett., 1987, 217, 81; C. Biolojan and A. Takai, Biochem. J., 1988, 256, 283; H. Fujiki and M. Suganuma, Adv. Cancer Res., 1993, 61, 143. S. Nishiwaki, M. Fujiki, M. Suganuma, M. Ojika, K. Yamada, and T. Sugimura, Biochem. Biophys. Research Commun., 1990, 170, 1359.
• K. Tachibana, P. J. Scheuer, Y. Tsukitani, H. Kikuchi, D. Van Enden, J. Clardy, Y. Gopichand, and F. J. Schmitz, J. Am. Chem. Soc., 1981, 103, 2469.
• T. Yasumoto, M. Murata, Y. Oshima, M. Sano, G. K. Matsumoto, and J. Clardy, Tetrahedron, 1985, 41, 1019; M. Murata, M. Shimatani, H. Sugitani, Y. Oshima, and T. Yasumoto, Bull. Jpn. Soc. Sci. Fish, 1992, 48, 549.
• M. Suganuma, H. Fujiki, H. Suguri, S. Yoshizawa, M. Hirota, M. Nakayasu, M. Ojika, K. Wakamatsu, K. Yamado, and T. Sugimura, Proc. Natl. Acad. Sci. USA, 1988, 85, 1768.
• J. T. Maynes, K. S. Bateman, M. M. Chemey, A. K. Das, H. -A. Luu, C. F. B. Holmes, and M. N. G. James, J. Biol. Chem., 2001, 276, 44078.

Terms in the title (10)： 蛋白質ホスファターゼ ,  PP1 ,  PP2A ,  阻害剤 ,  オカダ酸 ,  構造活性相関 ,  EPI ,  環 ,  ラクトン ,  類似体