Art

J-GLOBAL ID：200902299815551793   Reference number：03A0262853

N-Phenyl-N-purin-6-yl Ureas: The Design and Synthesis of P38α MAP Kinase Inhibitors.

N-フェニル-N-プリン-6-イルウレア化合物 P38α MAPキナーゼ阻害剤の設計と合成

Author (7)： WAN Z (GlaxoSmithKline Pharmaceuticals, PA, USA) ,  BOEHM J C (GlaxoSmithKline Pharmaceuticals, PA, USA) ,  BOWER M J (GlaxoSmithKline Pharmaceuticals, PA, USA) ,  KASSIS S (GlaxoSmithKline Pharmaceuticals, PA, USA) ,  LEE J C (GlaxoSmithKline Pharmaceuticals, PA, USA) ,  ZHAO B (GlaxoSmithKline Pharmaceuticals, PA, USA) ,  ADAMS J L (GlaxoSmithKline Pharmaceuticals, PA, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 13  Issue： 6  Page： 1191-1194  Publication year： Mar. 24, 2003 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： Suzukiカップリング反応

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=03A0262853&from=J-GLOBAL&jstjournalNo=W0248A") }}

JST classification (2)： Purines,pteridines  (CF07105E) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (25)： SB-203580 ,  2,6-Dichloro-9-methyl-9H-purine ,  2-Chloro-6-(methylthio)-9-methyl-9H-purine ,  2-(2-Methyl-4-fluorophenyl)-6-(methylsulfonyl)-9-methyl-9H-purine ,  2-(2-Methyl-4-fluorophenyl)-6-(2,6-difluorophenylamino)-9-methyl-9H-purine ,  N-Phenyl-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2-Chlorophenyl)-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(4-Fluorophenyl)-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2-Methoxyphenyl)-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(4-Chlorophenyl)-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,4,6-Trifluorophenyl)-N-carbamoyl-2-(2-methyl-4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-phenyl-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(3-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(4-fluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2,4-difluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(3,5-difluorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2-chlorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(3-chlorophenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2-methylphenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(3-methylphenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(4-methylphenyl)-9-methyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2-fluorophenyl)-9-benzyl-9H-purine-6-amine ,  N-(2,6-Difluorophenyl)-N-carbamoyl-2-(2-fluorophenyl)-9-[2-(dimethylamino)ethyl]-9H-purine-6-amine

Terms in the title (6)： フェニル ,  プリン ,  ウレア化合物 ,  p38α ,  MAPキナーゼ阻害剤 ,  設計