Research Project code：9910002205
Update date：Dec. 15, 2003
Clinicopathological study of neuropsychiatric disorder
1999 - 2001
Investigating Researcher (1)：
Although argyrophilic grain dementia (AGD) is a new concept of senile dementia, its pathologic observation and clinical behavior has not been fully clarified. Thus we investigated clinical pathology and past reports on 3 cases of AGD. Argyrophilic and tau-positive grains appear in the neuropin in the periphery of cerebrum, and most frequently in pes hippocampi, in 嗅内野(*) -経嗅内野(*), followed by hippocampal CAI and amygdaloid nucleus. In contrast to pyramidal neuron in this region showing diffuse tau-positive pretangle aspect, neurofibrillary tangle is only scantily observed. In the region of dense distribution of grains, tissues suffer porosis, accompanying light-medium neuronal dropout and degeneration comprising gliosis. In the white matter in the region of distributed grains are perceived many coiled bodies originating from oligodendroglia, and ballooned neurons scatter around amygdaloid nucleus. The grains themselves can appear in the case of Alzheimer-type dementia, Pick's disease, progressive supranuclear palsy and 資質(*) basal nuclei accompanying anomaly of cytoskeleton. These grains are a constituting factor of pathological observations of these diseases, but there exist cases (pure examples) in which major pathological observation is the appearance of many grains in the peripheral system of cerebrum as described above. Clinically, dementia was light and mainly comprised memory- and orientation disorder, personality change such as rejective tendency, accentuation of irritability and aggression, and poor sociability, unaccompanied with the Kluber-Bucy syndrome.
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