J-GLOBAL ID:200904030344804562  Research Project code:0150005620 Update date:Feb. 14, 2003

Regenerative engineering of high performance vessel wall: Material design, fabrication design and system's design

高機能血管壁再建技術 要素材料・要素技術とデバイス化
Study period:2000 - 2002
Organization (1):
Investigating Researcher (1):
Research overview:
(1) Molecular design of artificial extracellular matrix and development of gold stent: Extracellular matrix polymer (collagen, elastin, hyaluronic acid etc.). (2) Molecular design of photocurable artificial extracellular matrix: Development of materials and its processing technique using chemical modification of side chain of gelatin, hyaluronic acid, elastin, and heparin, and their radical polymerization induced by visible light. (3) Development of hydrogelation technique of stent substratum by disulfide bond formation between gold and thiol group chemically introduced to extracellular matrix (gelatin, heparin). (4) Development of gold stent using stereolithography: Covering stainless rod by photocurable resin with micropatterning made by stereolithography and its galvanoplasty in gold bath. Optimization of micropatterning, galvanoplastic membrane thickness, and annealing temperature to construct a structure with adequate mechanical properties. (5) Development of porous artificial acaffold: Establishment of automatic microprocessing technique of elastomer using excimer laser and development of technique to construct multi-tubular structure. Development of coating technique of artificial matrix described above. (6) Immobilization of bioactive substances and its evaluation by animal experiment: Selection of moderate anticoagulant, growth inhibitor, anti-arteriosclerosis gene to add drug delivery function on artificial blood vessel, covered stent, and strand, evaluation of their working mechanism by animal experiment and pathological evaluation of reconstructing process of blood vessel wall to construct basis for their clinical use. (k2001.10)
Keywords (7):
molecular design of artificial extracellular matrix ,  processing technique of photocurable artificial extracellular matrix ,  porous artificial scaffold ,  drug delivery system ,  artificial blood vessel ,  percutaneous intravascular surgery ,  tissue engineering for blood vessel
Project name: Regenerative Engineering of High Performance Vessel Wall: Material Design, Fabrication Design and System's Design
Project Organization (1):
  • Department of Biomedical Engineering, Graduate Schoolof Medicine, Kyushu University
Researcher representative of the project  (1):
  • MATSUDA Takehisa
Research program: Millennium Project
Ministry with control over the research :
Ministry of Education, Culture, Sports, Science and Technology
Research budget: 2001: \39,000,000

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