J-GLOBAL ID:200904032466343046  Research Project code:0450021039 Update date:Dec. 15, 2003

Studies in nuclear medicine: Relative PET measurements of cerebral blood flow and metabolism in hyper-acute ischemic stroke

核医学における研究 脳梗塞超急性期のPET測定に関する研究
Study period:2002 - 0
Organization (1):
Investigating Researcher (3):
Research overview:
Shimosegawa, Ibaraki et al. simplified the only one PET determination method of cerebral tissue oxygen metabolism and indicated the possibility of its application to emergent determination in acute phase cerebral infarction. The errors in the various circulatory variables in the simplified method were evaluated by simulation. In addition, the PET determination method was practically applied to a case of cerebral infarction under extremely acute phase within 6 hours after the incidence and the results were compared with those of simultaneously carried out MRI perfusion images and diffusion images to pathologically investigate the cerebral ischemic lesion. The results showed differences in the degree of declined cerebral oxygen metabolism in the mismatched area of MRI perfusion-diffusion images used as an indicator of thrombolytic therapy in acute phase cerebral infarction. Furthermore, a dissociated area from declined diffusion of water molecule expressing edematous tissue changes was observed. Determination of cerebral oxygen metabolism can differentiate these areas and defining these area shows capability of therapeutic prevention of cerebral infarction diffusion within several days after the attack. Experiences of improved determination procedure within 30 minutes period in emergent PET examination of the present method in 13 cases of acute phase cerebral infarction are comparable to that of conventional emergent SPECT examination solely used for cerebral blood flow volume determination.

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