Research Project code：9800034831
Update date：Nov. 21, 2003
1) Molecular mechanism for regulation of apoptosis 2) Molecular pathology on mitochondrial diseases 3) Regulation of gene expression of mitochondrial proteins
1) アポトーシス制御因子の分子機構,2) ミトコンドリア病の分子病態学,3) ミトコンドリアタンパク質の発現制御機構
1995 - 2003
Investigating Researcher (2)：
Studies in this laboratory originate from great interests i n apoptosis and mitochondria diseases. With studies on apoptosis, we have biochemically characterized members of bcl-2 family. Genetically engineered proteins of the family have been expressed in mammalian cells to elucidate biological functions of each family member. We are also interested in mitochondria diseases. Mitochondria from a variety of mitochondria disease patients have been introduced into a mammalian rho(o) cell which is a derivative of Hela cell and lacks mitochondria DNA. We are characterizing constructed cells carring a mutant mitochondria DNA in terms of gene experssion signal transduction and metabolism.
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