J-GLOBAL ID:200904037804098526  Research Project code:0150004027 Update date:Jun. 09, 2011

Mechanisms of signal transduction in skeletal development

Study period:2000 - 2003
Organization (1):
Investigating Researcher (3):
Research field (1): Other
Research overview:
The genes, which are related to chondrocyte maturation and specification of cartilage phenotype, are collected by screening using DNA chip and subtraction method. The functions of the candidate genes are analyzed by generating knockout mice and transgenic mice. From these experiments, we will isolate novel genes, which are responsible for chondrocyte maturation and specification of cartilage phenotype.
Keywords (5):
chondrocyte ,  permanent cartilage ,  transient cartilage ,  knockout mouse ,  transgenic mouse
Research program: Cooperative Research
Research budget: 2002: \3,709,000

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