J-GLOBAL ID:200904040993116093  Research Project code:9800045355 Update date:Dec. 13, 2002

Study of molecular regulatory mechanisms of mammalian development

Study period:1996 - 2000
Organization (1):
Investigating Researcher (4):
Research overview:
We have studied retinoic acid-inducible genes during F9 cell differentiation and found the rae28 gene, a member of the mammalian Polycomb group (Pc-G) of genes. The rae28-deficient mice showed that the rae28 gene is involved in the development of the skeletons, neural crest cells and hematopoiesis. Currently we are focusing on the following research projects. 1) Functional analysis of the Pc-G genes using the genetically engineered mice. We are interestied especially in their functions on neural crest development and hematopoiesis. 2) Molecular mechanisms regulating Hox gene expression. 3) Molecular mechanims regulating the Pc-G gene expression. 4) Analysis of the involvement of the Pc-G genes in human diseases.
Keywords (5):
mouse(animal) ,  neural ,  hematopoietic ,  gene ,  control
Research program: Ordinary Research
Research budget: 1997: \8,000,000

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