Research Project code：9800045355
Update date：Dec. 13, 2002
Study of molecular regulatory mechanisms of mammalian development
1996 - 2000
Investigating Researcher (4)：
We have studied retinoic acid-inducible genes during F9 cell differentiation and found the rae28 gene, a member of the mammalian Polycomb group (Pc-G) of genes. The rae28-deficient mice showed that the rae28 gene is involved in the development of the skeletons, neural crest cells and hematopoiesis. Currently we are focusing on the following research projects. 1) Functional analysis of the Pc-G genes using the genetically engineered mice. We are interestied especially in their functions on neural crest development and hematopoiesis. 2) Molecular mechanisms regulating Hox gene expression. 3) Molecular mechanims regulating the Pc-G gene expression. 4) Analysis of the involvement of the Pc-G genes in human diseases.
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