J-GLOBAL ID:200904041180918970  Research Project code:9800022518 Update date:Oct. 12, 2004

Molecular studies on human acute myeloid leukemia with chromosome translocation and development of gene therapy against leukemia

Study period:1990 - 0
Organization (1):
Investigating Researcher (2):
Research overview:
The precise mapping of chromosomal breakpoint on t(8:21) frequently observed in acute myeloid leukemia have led to the identification of a fused gene generated by the translocation. The molecular mechanism of leukemogenesis is studied by analyzing the function of the fused gene product. Gene therapy targeted against the fused gene is under investigation.
Keywords (9):
myelocytic ,  chromosome ,  translocation(genetics) ,  oncogene ,  molecular ,  leukemia ,  ribozyme ,  遺伝子療法 ,  リボザイム
Project Organization (1):
  • (E152000000)
Research program: Ordinary Research

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