J-GLOBAL ID:200904043491859121  Research Project code:9910002393 Update date:Nov. 18, 2002

Elucidation of the function of the protein encoded by thyroid hormone-responsive gene, ZAKI-4

Study period:1998 - 0
Organization (1):
Investigating Researcher (5):
Research overview:
A thyroid hormone-responsive gene, ZAKI-4 hasbeen cloned from human skin fibrobiasts. ZAKI-4 is abundantry expressed in brain and heart. This gene showshigh holomogy with DSCR-1 (Down Syndrome Critical Region-1), That is a candidate gene responsible for pathogenesis of Down Syndrome. Since both congenital hypothyroidism and Down syndrome cause severe mental retardation, itis hypothesized that products encoded by these genes play crucial roles in the brain development.
Keywords (6):
thyroid hormone ,  knockout Down Syndrome ,  hypothyroidism ,  central nervous sytem ,  heart ,  calaneurin
Researcher representative of the project  (1):
  • MURATA Yoshiharu
Research program: Ordinary Research

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