J-GLOBAL ID:200904060088359005  Research Project code:9800009781 Update date:Jan. 22, 1996

Regulation of lymphocyte differentiation and gene expression control

Study period:1988 - 1995
Organization (1):
Investigating Researcher (4):
Research overview:
One of our works is to elucidate the control mechanism of gene expression, such as immunoglobulin genes and T cell receptor genes during differentiation and maturation of lymphocytes from multipotential stem cells in bone marrow. Major subjects are 1) identification, purification and cloning of genes of nuclear factors which regulate transcription of the immunoglobulin genes, 2) elucidation of the role of such regulatory molecules on the lymphocyte differentiation, 3) analysis of immunological disorders caused by abnormal control of gene expression.
Keywords (9):
gene ,  B ,  differentiation(biology) ,  bone ,  stem ,  immunoglobulin ,  transcription(genetics) ,  immunologic ,  cellular
Research program: Ordinary Research
Research budget: 1995: \10,000,000

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