J-GLOBAL ID:200904072800943760  Research Project code:9800038925 Update date:Mar. 30, 2001

Influence of iodine on mass screening for congenital hypothyoroidism in Kochi Prefecture

Study period:1995 - 1999
Organization (1):
Investigating Researcher (1):
Research overview:
As a result of mass screening for congenital hypothyroidism in 1994, 15 infants were referred to close medical evaluation and four infants received I-thyroxine therapy. Of four, two infants had hypothyroidism caused by iodine excess due to iodinecontaining agents used for amninofetography. The TSH concentration in 149 infants was between 9 and 50 muU/ml of blood and a second dried blood specimen (DBS) was collected from them. In 138 out of 149 infants, the TSH concentration in the second DBSs were normal and they were considered to be false positive. The rate of requesting a second DBS varied from 0.0% to 11.1% among obstetric clinics in Kochi prefecture. The mean TSH concentration and the rate of requesting a second DBS were highest in the clinics where iodine-containing antiseptics were used for umbilical cord and applied to nasal cavity of infants. The mean TSH concentration and the rate of requesting a second DBS in two clinics where iodine-containing antispetics were applied to infants were significantly higher than those in the same clinics after changing to non-iodine-containing antiseptics. In conclusion, influence of iodine excess due to iodine-containing antiseptics on neonatal thyroid function may increase the false postive rate and the rete of close medical evaluation in Kochi prefecture, which are higher than those of the national average.
Keywords (11):
hypothyroidism ,  newborn infant disease ,  congentinal disease ,  organoiodine compound ,  contrast media ,  fetus ,  blood examination ,  screening(inspection) ,  germicide ,  blood collection ,  urine analysis
Research program: Ordinary Research
Research budget: 1997: \0

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