Research Project code：9800022630
Update date：Mar. 17, 1998
The immunopathogensesis and morphogenesis of heart disease molecular biologic implications
1991 - 1999
Investigating Researcher (9)：
To clarify the relationship between cardiac diseases and the myosin heavy chain (MHC) gene, partial sequencing of the human genomic LMM portion of the cardiac alpha-MHC gene was performed. The human cardiac alpha and beta-MHC genes were mapped to chromosome region 14q11.2-q13. This region includes genes for T cell receptor alpha polypeptide and nucleoside phoshphorylase which may control development of myocardial autoantibodies and predisposition to autoimmune myocarditis, respectively, as in the mouse. This study aims to elucidate the immunopathogenesis and morphogenesis of cardiovascular disease such as hypertrophic cardiomyopathy, long QT syndrome, CATCH 22 Williams syndrome and Holt-Oram syndrome.
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