J-GLOBAL ID:200904077275659284  Research Project code:9800022630 Update date:Mar. 17, 1998

The immunopathogensesis and morphogenesis of heart disease molecular biologic implications

心臓病成因解明に関する研究 遺伝子工学を用いた心臓病と免疫機構の相関研究ならびに心血管形態形成異常成因の研究
Study period:1991 - 1999
Organization (1):
Investigating Researcher (9):
Research overview:
To clarify the relationship between cardiac diseases and the myosin heavy chain (MHC) gene, partial sequencing of the human genomic LMM portion of the cardiac alpha-MHC gene was performed. The human cardiac alpha and beta-MHC genes were mapped to chromosome region 14q11.2-q13. This region includes genes for T cell receptor alpha polypeptide and nucleoside phoshphorylase which may control development of myocardial autoantibodies and predisposition to autoimmune myocarditis, respectively, as in the mouse. This study aims to elucidate the immunopathogenesis and morphogenesis of cardiovascular disease such as hypertrophic cardiomyopathy, long QT syndrome, CATCH 22 Williams syndrome and Holt-Oram syndrome.
Keywords (5):
genome ,  gene ,  cardiomyopathy ,  gene ,  nucleotide
Research program: Ordinary Research
Research budget: 1997: \10,000,000

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