Proj
J-GLOBAL ID:200904081617297093  Research Project code:9800022794 Update date:Dec. 15, 2003

Study of environmental factors on lung carcinogenesis

肺癌発生の環境因子に関する研究
Study period:1991 - 1999
Organization (1):
Investigating Researcher (3):
Research overview:
Effect of potent carcinogens, aspirated from atmosphere and deposit in lung tissue, are analyzed. Study on benzopyrene and nitropyrene as a lung carcinogen is on going. In Fuyuan, Yunnan Province, China, high lung cancer mortality was related to indoor coal conbustion emission and high benzo(a)pyrene content in the coal. On the other hand, in Japanese lung cancer patients high concentration of nitropyrenes were detected in their lung tissues. High concentrations of nitroarenes (such as 1-nitropyrene, dinitropyrene and nitrofluoranthene) correlated with poorly differentiated phenotype and poor prognosis of the patients with lung cancer. By animal experiment, it was suggested that 1-nitropyrene induce lung adenocarcinoma in A/J mice, at least in part, by the induction of K-ras gene mutation. Benzopyrene and 1-nitropyrene induced the expression of wild-type p53 protein in bronchial epithelial cells. The study on molecular mechanism of lung cercinogenesis by environmental carcinogens are ongoing.
Keywords (6):
lung cancer ,  henzo(a)pyrene ,  carcinogen ,  1-nitropyrene ,  oncogene ,  p53
Research program: Ordinary Research
Research budget: 1997: \1,000,000

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