Research Project code：9800022794
Update date：Dec. 15, 2003
Study of environmental factors on lung carcinogenesis
1991 - 1999
Investigating Researcher (3)：
Effect of potent carcinogens, aspirated from atmosphere and deposit in lung tissue, are analyzed. Study on benzopyrene and nitropyrene as a lung carcinogen is on going. In Fuyuan, Yunnan Province, China, high lung cancer mortality was related to indoor coal conbustion emission and high benzo(a)pyrene content in the coal. On the other hand, in Japanese lung cancer patients high concentration of nitropyrenes were detected in their lung tissues. High concentrations of nitroarenes (such as 1-nitropyrene, dinitropyrene and nitrofluoranthene) correlated with poorly differentiated phenotype and poor prognosis of the patients with lung cancer. By animal experiment, it was suggested that 1-nitropyrene induce lung adenocarcinoma in A/J mice, at least in part, by the induction of K-ras gene mutation. Benzopyrene and 1-nitropyrene induced the expression of wild-type p53 protein in bronchial epithelial cells. The study on molecular mechanism of lung cercinogenesis by environmental carcinogens are ongoing.
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