J-GLOBAL ID:200904083429704652  Research Project code:9800040170 Update date:Nov. 12, 2001

Biochemical and immunochemical study on the onset mechanism of muscular dystrophy

Study period:1983 - 2000
Organization (1):
Investigating Researcher (2):
Research overview:
Muscular dystrophy is a disease which develops progressive degradation of myofibrils. Duchenne and Becker types of this disease have a defect of dystrophin-gene. In our study, we have developed to detect dystrophin on two dimmensional electrophoresis and revealed this method to be useful for clinical diagnosis. Recently we could also find the new serine proteinase designated myonase from muscular dystrophic mouse skeletal muscle. Now, we are studying to reveal the function of myonase and its relation to muscular dystrophy.
Keywords (5):
muscular dystrophy ,  skeletal muscle ,  atrophy(disease) ,  gene therapy ,  proteolytic enzymes
Research program: Ordinary Research

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