J-GLOBAL ID:200904084980497834  Research Project code:9800038045 Update date:Feb. 03, 2005

Study of structure-function relationship of hemoglobin by computer simulation

Study period:1995 - 0
Organization (1):
Investigating Researcher (1):
Research overview:
Molecular mechanism of cooperative oxygen binding to hemoglobin is studied by rapid vector computation of conformation energy function of tetrameric hemoglobin and its first and second derivatives. First, minimum energy conformations of T-and R-state hemoglobin are obtained from X-ray structures of hemoglobin. Secondly, relatively small conformation change and energy change upon oxygen binding to these T-and R-state hemoglobin are simulated also by energy minimization.
Keywords (6):
hemoglobin ,  computation ,  oxygen-binding ,  酸素 ,  吸着 ,  立体構造
Project Organization (1):
  • (2224525000)
Research program: Ordinary Research
Research budget: 1996: \400,000

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