Research Project code：9800038045
Update date：Feb. 03, 2005
Study of structure-function relationship of hemoglobin by computer simulation
1995 - 0
Investigating Researcher (1)：
Molecular mechanism of cooperative oxygen binding to hemoglobin is studied by rapid vector computation of conformation energy function of tetrameric hemoglobin and its first and second derivatives. First, minimum energy conformations of T-and R-state hemoglobin are obtained from X-ray structures of hemoglobin. Secondly, relatively small conformation change and energy change upon oxygen binding to these T-and R-state hemoglobin are simulated also by energy minimization.
Project Organization (1)：
Return to Previous Page